Environmental Factors Affecting Growth and Occurrence of Testicular Cancer in Childhood: An Overview of the Current Epidemiological Evidence.
Environmental Factors Affecting Growth and Occurrence of Testicular Cancer in Childhood: An Overview of the Current Epidemiological Evidence.
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DOI：
10.3390/children4010001
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发表时间：
2017-01-05
期刊：
影响因子：
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通讯作者：
Fargnoli S
中科院分区：
文献类型：
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作者：
Giannandrea F;Fargnoli S
睾丸癌（TC）是15-34岁青少年和年轻男性中最常见的恶性肿瘤。尽管在过去的40年里，在一些西方国家，TC的发病率一直在上升，但对这种上升的解释仍然不确定。据推测，早期生活暴露于许多职业和环境雌激素化学品，如内分泌干扰化学品（EDCs），可能在TC的病因学中发挥作用，但该主题仍然是开放的进一步调查。最近，也有人提出，与儿童生长发育相关的产前和产后环境暴露也可能参与TC进展。本文回顾了当前流行病学研究（2000-2015），旨在确定与TC相关的环境因素，特别关注可能构成疾病发展风险的婴儿和儿童因素。它也可能有助于认识到知识的差距和最近的研究要求TC，并指出可能的相互作用，儿童的生长和发育有关的产前和产后环境暴露。
Testicular cancer (TC) is the most frequently occurring malignancy among adolescents and young men aged 15–34 years. Although incidence of TC has been growing over the past 40 years in several western countries, the explanations for this increase still remain uncertain. It has been postulated that early life exposure to numerous occupational and environmental estrogenic chemicals, such as endocrine-disrupting chemicals (EDCs), may play a contributing role in the etiology of TC, but the subject is still open to additional investigation. Recently, it has also been suggested that prenatal and postnatal environmental exposures associated with child growth and development might also be involved in TC progression. This review of current epidemiological studies (2000–2015) aims to identify environmental factors associated with TC, with a particular focus on infancy and childhood factors that could constitute a risk for disease development. It may also contribute towards recognizing gaps in knowledge and recent research requirements for TC, and to point out possible interactions between child growth and development in relation to prenatal and postnatal environmental exposures.