Effects of anti-angiogenesis on glioblastoma growth and migration: model to clinical predictions.
Effects of anti-angiogenesis on glioblastoma growth and migration: model to clinical predictions.
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DOI：
10.1371/journal.pone.0115018
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发表时间：
2014
期刊：
影响因子：
3.7
通讯作者：
Fathallah-Shaykh HM
中科院分区：
文献类型：
--
作者：
Scribner E;Saut O;Province P;Bag A;Colin T;Fathallah-Shaykh HM
Glioblastoma multiforme (GBM) causes significant neurological morbidity and short survival times. Brain invasion by GBM is associated with poor prognosis. Recent clinical trials of bevacizumab in newly-diagnosed GBM found no beneficial effects on overall survival times; however, the baseline health-related quality of life and performance status were maintained longer in the bevacizumab group and the glucocorticoid requirement was lower. Here, we construct a clinical-scale model of GBM whose predictions uncover a new pattern of recurrence in 11/70 bevacizumab-treated patients. The findings support an exception to the Folkman hypothesis: GBM grows in the absence of angiogenesis by a cycle of proliferation and brain invasion that expands necrosis. Furthermore, necrosis is positively correlated with brain invasion in 26 newly-diagnosed GBM. The unintuitive results explain the unusual clinical effects of bevacizumab and suggest new hypotheses on the dynamic clinical effects of migration by active transport, a mechanism of hypoxia-driven brain invasion.
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DOI：
10.1038/nrc2442
发表时间：
2008-08
期刊：
Nature reviews. Cancer
影响因子：
--
作者：
通讯作者：
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影响因子：
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作者：
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DOI：
10.1073/pnas.1014480108
发表时间：
2011-03-01
影响因子：
11.1
作者：
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影响因子：
15.9
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通讯作者：
Oldfield, EH