Correction.
Correction.
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更正。
DOI：
10.1021/ja403136h
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发表时间：
2013
影响因子：
15
通讯作者：
中科院分区：
文献类型：
--
作者：
临床试验通常依靠超声心动图测量左心室（LV）的大小和功能作为替代终点。然而，影响这些测量可重复性的因素的定量影响尚不清楚。为了解决这个问题，nhlbi资助的儿科心脏网络设计了一项纵向观察研究，研究对象是来自8个儿科临床中心的0-22岁已知或疑似扩张型心肌病（DCM）的儿童。方法：收集临床资料及150项左室大小、功能超声心动图指标。不同的观察者进行了重复的超声心动图成像。多名观察员从三个心脏周期进行测量，以评估内和
Clinical trials often rely on echocardiographic measures of left ventricular (LV) size and function as surrogate end-points. However, the quantitative impact of factors that affect reproducibility of these measures is unknown. To address this issue, the NHLBI-funded Pediatric Heart Network designed a longitudinal observational study of children with known or suspected dilated cardiomyopathy (DCM) aged 0–22 years from 8 pediatric clinical centers.Methods—Clinical data were collected together with 150 echocardiographic indices of LV size and function. Separate observers performed duplicate echocardiographic imaging. Multiple observers performed measurements from three cardiac cycles to enable assessment of intra and