Inhaled albuterol increases estimated ventilatory capacity in nonasthmatic children without and with obesity.
Inhaled albuterol increases estimated ventilatory capacity in nonasthmatic children without and with obesity.
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DOI：
10.1016/j.resp.2020.103597
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发表时间：
2021-03
影响因子：
2.3
通讯作者：
Babb TG
中科院分区：
文献类型：
--
作者：
Wilhite DP;Bhammar DM;Balmain BN;Martinez-Fernandez T;Babb TG
Forced mid-expiratory flow (i.e., isoFEF25-75) may increase with a short-acting β2-agonist in nonasthmatic children without bronchodilator responsiveness. This could also increase estimated ventilatory capacity along mid-expiration (ecap25-75), especially in vulnerable children with obesity who exhibit altered breathing mechanics. We estimated ecap25-75 pre- and post-albuterol treatment in 8-12yo children without (n=28) and with (n=46) obesity. A two-way ANOVA was performed to determine effects of an inhaled bronchodilator (pre-post) and obesity (group) on isoFEF25-75 and ecap25-75. There was no group by bronchodilator interaction or main group effect on outcome variables. However, a significant main effect of the bronchodilator was detected in spirometry parameters, including a substantial increase in isoFEF25-75 (17.1±18.0%) and only a slight (non-clinical) but significant increase in FEV1 (2.4±4.3%). ecap25-75 significantly increased with albuterol (+11.7±10.6L/min; +15.8±13.9%). These findings imply potentially important increases in ventilatory reserve with a bronchodilator in nonasthmatic children without and with obesity, which could potentially influence respiratory function at rest and during exercise.
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影响因子：
4.1
作者：
Bhammar DM;Stickford JL;Bernhardt V;Babb TG
通讯作者：
Babb TG
影响因子：
158.5
作者：
HOGG, JC;MACKLEM, PT;THURLBECK, WM
通讯作者：
THURLBECK, WM
影响因子：
3.3
作者：
GREEN, M;MEAD, J;TURNER, JM
通讯作者：
TURNER, JM
影响因子：
5.5
作者：
Dominelli, Paolo B.;Foster, Glen E.;Sheel, A. William
通讯作者：
Sheel, A. William
DOI：
10.1378/chest.43.4.382
发表时间：
1963-01-01
期刊：
DISEASES OF THE CHEST
影响因子：
--
作者：
BARTLETT, RG;PHILLIPS, NE;WOLSKI, G
通讯作者：
WOLSKI, G