Cognitive and neuroimaging evidence of impaired interaction between self and memory in Alzheimer's disease
Cognitive and neuroimaging evidence of impaired interaction between self and memory in Alzheimer's disease
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DOI：
10.1016/j.cortex.2013.06.009
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发表时间：
2014-02-01
期刊：
影响因子：
3.6
通讯作者：
Bastin, Christine
中科院分区：
文献类型：
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作者：
Genon, Sarah;Bahri, Mohamed Ali;Bastin, Christine
在人类认知中，自我和记忆过程强烈地相互作用，如对自我参照材料的记忆优势[自我参照效应（SRE）和自我参照回忆效应（SRRE）]所证明的。目前的研究在行为水平上检查了这种相互作用及其与阿尔茨海默病（AD）患者的神经相关性。健康的老年人控制（HC）和AD患者进行特质形容词判断自我相关性或其他相关性（编码阶段）。在第一个实验中，编码和随后的是非识别阶段在磁共振成像（MRI）扫描仪中进行。在自我相关判断过程中，通过功能性磁共振成像（fMRI）检测大脑激活，并使用解剖图像来搜索自我相关项目的记忆优势与灰质密度（GMD）之间的相关性。在第二个实验中，参与者描述了驱动他们识别决策的检索体验（熟悉性与回忆性体验）。行为学结果显示，与HC参与者相比，AD患者的SEE和SRRE受损。此外，口头报告显示，检索的自我相关的信息优先与检索的上下文细节，如源记忆在HC参与者，但在AD患者较少。我们的成像结果显示，两组激活内侧前额叶皮层（MPFC）在编码过程中的自我相关判断。然而，变量和有限的记忆优势，自我相关的信息与GMD在侧前额叶皮层的AD患者，一个区域支持高阶过程连接自我和记忆。这些研究结果表明，即使AD患者在自我参照判断过程中参与MPFC，自我相关记忆的检索也会在定性和定量上受到损害，这与侧PFC中的高阶过程改变有关。（C）2013 Elsevier Ltd.保留所有权利。
In human cognition, self and memory processes strongly interact, as evidenced by the memory advantage for self-referential materials [Self-Reference Effect (SRE) and Self-Reference Recollection Effect (SRRE)]. The current study examined this interaction at the behavioural level and its neural correlates in patients with Alzheimer's disease (AD). Healthy older controls (HC) and AD patients performed trait-adjectives judgements either for self-relevance or for other-relevance (encoding phase). In a first experiment, the encoding and subsequent yes no recognition phases were administrated in a Magnetic Resonance Imaging (MRI) scanner. Brain activation as measured by functional MRI (fMRI) was examined during self-relevance judgements and anatomical images were used to search for correlation between the memory advantage for self-related items and grey matter density (GMD). In a second experiment, participants described the retrieval experience that had driven their recognition decisions (familiarity vs recollective experience). The behavioural results revealed that the SEE and SRRE were impaired in AD patients compared to HC participants. Furthermore, verbal reports revealed that the retrieval of self-related information was preferentially associated with the retrieval of contextual details, such as source memory in the HC participants, but less so in the AD patients. Our imaging findings revealed that both groups activated the medial prefrontal cortex (MPFC) at encoding during self-relevance judgements. However, the variable and limited memory advantage for self-related information was associated with GMD in the lateral prefrontal cortex in the AD patients, a region supporting high-order processes linking self and memory. These findings suggest that even if AD patients engage MPFC during self-referential judgements, the retrieval of self-related memories is qualitatively and quantitatively impaired in relation with altered high-order processes in the lateral PFC. (C) 2013 Elsevier Ltd. All rights reserved.