Variable selection for discrete survival model with frailty in presence of left truncation and right censoring: Studying association of environmental toxicants on time-to-pregnancy.
Variable selection for discrete survival model with frailty in presence of left truncation and right censoring: Studying association of environmental toxicants on time-to-pregnancy.
复制标题
在存在左截断和右审查的情况下，离散生存模型的变量选择：研究环境毒物与怀孕时间的关联。
DOI：
10.1002/sim.9609
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发表时间：
2023
影响因子：
2
通讯作者：
Sundaram,Rajeshwari
中科院分区：
文献类型：
--
作者：
Saha,Abhisek;Sundaram,Rajeshwari
了解环境毒物的混合物和怀孕时间（TTP）之间的关联是一个重要的科学问题，因为已经有足够的证据表明个别毒物对生殖健康的影响，以及个人暴露于一系列毒物而不是个别毒物。评估化学品混合物对TTP的影响带来了重大的统计挑战，即（i）TTP是一个离散的生存结果，通常受到左截断和右删失的影响，（ii）化学品暴露具有很强的相关性，（iii）考虑到一些与脂质结合的化学品，（iv）一些化学品的非线性影响，以及（v）某些化学品的高百分比浓度低于检测限（LOD）。我们提出了一个离散的脆弱性建模框架（命名为Discnet），允许选择相关的风险，同时解决上述问题。Discnet被证明有更好的和稳定的FN和FP率相比，在各种模拟设置的替代方法。我们对LIFE研究进行了详细分析，涉及多氯联苯和怀孕时间，发现老年女性，女性暴露于可替宁（吸烟），DDT会延迟怀孕，这在之前的敏感性分析中是一致的，以解释LOD以及非线性关联。
Understanding the association between mixtures of environmental toxicants and time-to-pregnancy (TTP) is an important scientific question as sufficient evidence has emerged about the impact of individual toxicants on reproductive health and that individuals are exposed to a whole host of toxicants rather than an individual toxicant. Assessing mixtures of chemicals effects on TTP poses significant statistical challenges, namely (i) TTP being a discrete survival outcome, typically subject to left truncation and right censoring, (ii) chemical exposures being strongly correlated, (iii) accounting for some chemicals that bind to lipids, (iv) non-linear effects of some chemicals, and (v) high percentage concentration below the limit of detection (LOD) for some chemicals. We propose a discrete frailty modeling framework (named Discnet) that allows selection of correlated exposures while addressing the issues mentioned above. Discnet is shown to have better and stable FN and FP rates compared to alternative methods in various simulation settings. We did a detailed analysis of the LIFE Study, pertaining to polychlorinated biphenyls and time-to-pregnancy and found that older females, female exposure to cotinine (smoking), DDT conferred a delay in getting pregnant, which was consistent across prior sensitivity analyses to account for LOD as well as non-linear associations.