Animal models of Alzheimer's disease and drug development.
Animal models of Alzheimer's disease and drug development.
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DOI：
10.1016/j.ddtec.2012.04.001
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发表时间：
2013-09-01
期刊：
影响因子：
--
通讯作者：
Rahman, Anisur
中科院分区：
文献类型：
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作者：
Laurijssens, Bart;Aujard, Fabienne;Rahman, Anisur
动物疾病模型被认为在阿尔茨海默病药物的开发中很重要。这篇简短的综述将讨论为什么他们在确定有效治疗方面的成功有限的可能原因，并将提供一些关于动物实验在药物开发中的作用的想法。具体来说，目前没有一个阿尔茨海默病模型具有结构或预测有效性，而且可能永远不会有模型。显然，特定的动物实验有助于我们对疾病的理解并产生假设。然而，最终，这一假设只能在人类患者中进行测试，而且只能使用适当的工具。这些工具是一种积极的干预（在人类）和临床试验，适合于评估的作用机制。在这一过程中，知识在定量（子）模型中的整合即使不是必不可少的，也被认为是重要的。
Animal disease models are considered important in the development of drugs for Alzheimer's disease. This brief review will discuss possible reasons why their success in identifying efficacious treatments has been limited, and will provide some thoughts on the role of animal experimentation in drug development. Specifically, none of the current models of Alzheimer's disease have either construct or predictive validity, and no model probably ever will. Clearly, specific animal experiments contribute to our understanding of the disease and generate hypotheses. Ultimately, however, the hypothesis can only be tested in human patients and only with the proper tools. These tools are a pharmacologically active intervention (in humans) and a clinical trial suited to evaluate the mechanism of action. Integration of knowledge in quantitative (sub) models is considered important if not essential in this process.