Noninvasive magnetic resonance/photoacoustic imaging for photothermal therapy response monitoring
Noninvasive magnetic resonance/photoacoustic imaging for photothermal therapy response monitoring
复制标题
用于光热治疗反应监测的无创磁共振/光声成像
作者：
Ye Jing;Fu Guifeng;Yan Xiaohui;Liu Jingyi;Wang Xiaoyong;Cheng Liang;Zhang Fan;Sun Phillip Zhe;Liu Gang
血管通透性和治疗反应的体内评估为目前正在进行临床研究的光热疗法（PTT）提供了新的见解。我们开发了无创成像策略，以改善对纳米颗粒介导的 PTT 反应的监测，以实现个性化纳米医学。简而言之，应用动态对比增强磁共振成像（DCE-MRI）和光声成像（PAI）研究不同微血管通透性的肿瘤模型（即4T1小鼠乳腺肿瘤模型和HUH-7人肝癌裸鼠模型）中的增强渗透性和保留（EPR）效应。磁共振温度成像（MRTI）和扩散加权MRI（DWI）显示4T1肿瘤模型表现出比HUH-7肿瘤模型更高的PTT温度响应。我们的研究结果表明，MRI 和 PAI 技术的联合使用可用于监测 PTT 后的血管通透性和温度状态，有望在未来的转化研究中帮助指导 PTT。
In vivo assessment of vascular permeability and therapeutic response provides novel insights into photothermal therapy (PTT) that is currently under clinical investigation. We have developed noninvasive imaging strategies to improve the monitoring of nanoparticle-mediated PTT responses for personalized nanomedicine. Briefly, dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) and photoacoustic imaging (PAI) were applied to study the enhanced permeability and retention (EPR) effect in tumor models of different microvascular permeabilities (i.e., 4T1 mouse breast tumor model and HUH-7 human hepatoma model in nude mice). Magnetic resonance temperature imaging (MRTI) and diffusion-weighted MRI (DWI) showed that the 4T1 tumor model exhibits a higher PTT temperature response than that of the HUH-7 tumor model. Our findings demonstrate that the combined use of MRI and PAI techniques is useful in monitoring the vascular permeability and temperature status following PTT, promising to help guide PTT in future translational investigation.