Mitotic spindle morphogenesis in animal cells.

Mitotic spindle morphogenesis in animal cells.
复制标题

动物细胞有丝分裂纺锤体形态发生。

DOI:
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发表时间:
1991
期刊:
Seminars in Cell Biology
影响因子:
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通讯作者:
E. Karsenti
E. Karsenti
中科院分区:
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文献类型:
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作者:
E. Karsenti

文献摘要

被引文献

相似文献

有丝分裂纺锤体的组装是细胞水平形态发生的一个有趣的例子。这一重大事件的时间控制涉及周期蛋白-cdc 2激酶复合物的周期性激活。在这篇综述中,我报告了最近的结果,揭示了一些光的时间调节中心体复制,微管成核和微管动力学。高动态微管重组成一个双极纺锤体可能需要驱动蛋白和动力蛋白样电机和他们的作用进行了讨论,在一个假设的模型,可能适用于所有的有丝分裂纺锤体。
Assembly of the mitotic spindle is an interesting example of morphogenesis at the cellular level. The temporal control of this major event involves the periodic activation of the cyclin-cdc2 kinase complex. In this review, I report recent results that have shed some light on the temporal regulation of centrosome duplication, microtubule nucleation and microtubule dynamics. Reorganization of highly dynamic microtubules into a bipolar spindle probably requires kinesin and dynein-like motors and their role is discussed in an hypothetical model that may be applicable to all mitotic spindles.