Mitotic spindle morphogenesis in animal cells.
Mitotic spindle morphogenesis in animal cells.
复制标题
动物细胞有丝分裂纺锤体形态发生。
DOI:
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发表时间:
1991
期刊:
影响因子:
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通讯作者:
E. Karsenti
中科院分区:
文献类型:
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作者:
E. Karsenti
Assembly of the mitotic spindle is an interesting example of morphogenesis at the cellular level. The temporal control of this major event involves the periodic activation of the cyclin-cdc2 kinase complex. In this review, I report recent results that have shed some light on the temporal regulation of centrosome duplication, microtubule nucleation and microtubule dynamics. Reorganization of highly dynamic microtubules into a bipolar spindle probably requires kinesin and dynein-like motors and their role is discussed in an hypothetical model that may be applicable to all mitotic spindles.