The System Design, Engineering Architecture, and Preliminary Results of a Lower-Cost High-Sensitivity High-Resolution Positron Emission Mammography Camera.
The System Design, Engineering Architecture, and Preliminary Results of a Lower-Cost High-Sensitivity High-Resolution Positron Emission Mammography Camera.
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DOI：
10.1109/tns.2009.2031644
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发表时间：
2010-02-01
影响因子：
1.8
通讯作者：
Wong WH
中科院分区：
文献类型：
--
作者：
Zhang Y;Ramirez RA;Li H;Liu S;An S;Wang C;Baghaei H;Wong WH
研制了一种低成本、高灵敏度、高分辨率的正电子发射乳腺摄影(PEM)相机。它由两个探测器模块组成，平面探测器组为20×12 cm~2。每个存储体具有60个低成本的PMT象限共享(PQ)LYSO块，以具有两种类型的几何结构的10×6阵列排列。一种是对称的19.36×19.36 mm~2块，由1.5×1.5×10 mm~3晶体组成的12×12阵列。另一种是由1.5×1.9×10 mm~3晶体组成的12×13阵列的19.36×26.05 mm~2非对称块。在常规PQS设计中，沿着组的一侧使用一行(10)细长块来回收半空的PMT光电阴极，以减少模块边缘的死区。该组分具有高达88%的整体晶体填充分数，这导致了非常高的灵敏度。为了低成本、紧凑和稳定的目的，已经开发了机械设计和电子设备。每个模块都有四个愤怒超解码电子设备，可以处理单次事件3MCPS的计数速率。研制了一种具有硬件延迟窗口的简易双模块符合板，可实现6~15 ns的可调窗口。通过初步测试和蒙特卡罗模拟对部分性能参数进行了研究，包括探测器的晶体解码图和17%的能量分辨率，50 mm组到组距离时11.5%的点源灵敏度，1.2 mm的空间分辨率，7.0MCI人体总活动量下42kcps的峰值噪声当量计数率，以及分辨率体模图像。这些结果表明，实现了构建低成本、高灵敏度、高分辨率的质子交换膜探测器的设计目标。
A lower-cost high-sensitivity high-resolution positron emission mammography (PEM) camera is developed. It consists of two detector modules with the planar detector bank of 20 × 12 cm2. Each bank has 60 low-cost PMT-Quadrant-Sharing (PQS) LYSO blocks arranged in a 10 × 6 array with two types of geometries. One is the symmetric 19.36 × 19.36 mm2 block made of 1.5 × 1.5 × 10 mm3 crystals in a 12 × 12 array. The other is the 19.36 × 26.05 mm2 asymmetric block made of 1.5 × 1.9 × 10 mm3 crystals in 12 × 13 array. One row (10) of the elongated blocks are used along one side of the bank to reclaim the half empty PMT photocathode in the regular PQS design to reduce the dead area at the edge of the module. The bank has a high overall crystal packing fraction of 88%, which results in a very high sensitivity. Mechanical design and electronics have been developed for low-cost, compactness, and stability purposes. Each module has four Anger-HYPER decoding electronics that can handle a count-rate of 3 Mcps for single events. A simple two-module coincidence board with a hardware delay window for random coincidences has been developed with an adjustable window of 6 to 15 ns. Some of the performance parameters have been studied by preliminary tests and Monte Carlo simulations, including the crystal decoding map and the 17% energy resolution of the detectors, the point source sensitivity of 11.5% with 50 mm bank-to-bank distance, the 1.2 mm-spatial resolutions, 42 kcps peak Noise Equivalent Count Rate at 7.0-mCi total activity in human body, and the resolution phantom images. Those results show that the design goal of building a lower-cost, high-sensitivity, high-resolution PEM detector is achieved.