Dynamic imaging of chemokine-dependent CD8+ T cell help for CD8+ T cell responses
Dynamic imaging of chemokine-dependent CD8+ T cell help for CD8+ T cell responses
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DOI：
10.1038/ni1495
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发表时间：
2007-09-01
影响因子：
30.5
通讯作者：
Fetler, Luc
中科院分区：
文献类型：
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作者：
Hugues, Stephanie;Scholer, Alix;Fetler, Luc
幼稚T淋巴细胞在淋巴组织中有效地移动，同时扫描树突状细胞以寻找主要组织相容性分子中肽的同源复合物。然而，T细胞迁移在识别同源抗原后停止。我们发现在抗原特异性CD8（+）T细胞应答的启动过程中，初始CD8（+）多克隆T细胞“优先”以抗原非依赖性方式与能够将抗原呈递给抗原特异性CD8（+）T细胞的成熟树突状细胞相互作用。这些抗原非依赖性相互作用需要多克隆T细胞上的趋化因子受体CCR5的表达，并增加诱导幼稚、低前体频率CD8（+）T细胞应答的效率。因此，抗原特异性CD8（+）T细胞通过促进多克隆CD8（+）T细胞向成熟树突状细胞的CCR5依赖性募集而有利于初始CD8（+）T细胞的引发。
Naive T lymphocytes move efficiently in lymphoid tissues while scanning dendritic cells in search of cognate complexes of peptide in major histocompatibility molecules. However, T cell migration ceases after recognition of cognate antigen. We show here that during the initiation of antigen-specific CD8(+) T cell responses, naive CD8(+) polyclonal T cells 'preferentially' interacted in an antigen-independent way with mature dendritic cells competent to present antigen to antigen-specific CD8(+) T cells. These antigen-independent interactions required expression of the chemokine receptor CCR5 on polyclonal T cells and increased the efficiency of the induction of naive, low-precursor-frequency CD8(+) T cell responses. Thus, antigen-specific CD8(+) T cells favor the priming of naive CD8(+) T cells by promoting the CCR5-dependent recruitment of polyclonal CD8(+) T cells to mature dendritic cells.