Sensorineural hearing loss degrades behavioral and physiological measures of human spatial selective auditory attention.
Sensorineural hearing loss degrades behavioral and physiological measures of human spatial selective auditory attention.
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DOI：
10.1073/pnas.1721226115
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发表时间：
2018-04-03
影响因子：
11.1
通讯作者：
Shinn-Cunningham BG
中科院分区：
文献类型：
--
作者：
Dai L;Best V;Shinn-Cunningham BG
听力受损的听众在许多社交场合都有沟通方面的困难。在这种情况下，听力正常的听者会抑制竞争声音的神经表征，这一过程被称为听觉选择性注意。我们比较了听力受损(HI)和听力正常(NH)听者在空间选择性注意任务中的表现，同时使用脑电图法测量神经反应。与NH听者相比，HI听者对空间线索的敏感性更差，在选择性注意任务中的表现更差，对竞争声音的神经抑制更弱。此外，这些不同的衡量标准对于HI和NH听众来说都是相关的。这些结果表明，空间敏锐度差会产生选择性注意问题。这些发现对基础科学和下一代助听器的开发都有意义。感觉神经性听力损失的听众在听懂其他声音时往往会有困难。虽然空间听力差往往与此有关，但直接证据很弱；此外，研究表明，可听性降低和频谱编码退化可能解释了这些问题。我们假设，空间敏锐度差会导致难以运用选择性注意力，而选择性注意力通常会过滤掉令人分心的声音。在听力正常的听者中，选择性注意力会引起由竞争声音引起的神经反应的变化，这可以用来量化注意力控制的有效性。在这里，我们使用行为和脑电图来探索听力受损(HI)听者对选择性听觉注意的控制是否下降。正常听力(NH)和听力障碍(HI)受试者识别出一个简单的旋律，同时呈现两个相互竞争的旋律，每个旋律都从不同的横向角度模拟。我们量化了由这些相互竞争的流引起的大脑皮质反应的表现和注意调节。与NH听者相比，HI听者对空间线索的敏感度较差，在选择性注意任务中的表现较差，对皮层反应的注意调节也较差。此外，在NH和HI个体中，这些测量是相关的。虽然两组受试者都表现出对干扰流的皮质抑制，但这种调制在HI听者中较弱，特别是当注意到中线上的目标时，周围有竞争的流。这些发现表明，听力损失干扰了根据位置过滤声源的能力，导致社交场合中的沟通困难。这些发现对旨在使用神经信号来指导助听器处理的技术也有意义。
Listeners with hearing loss have trouble communicating in many social settings. In such situations, listeners with normal hearing suppress the neural representation of competing sounds, a process known as auditory selective attention. We compared hearing-impaired (HI) and normal-hearing (NH) listeners on a spatial selective attention task while measuring neural responses using electroencephalography. Compared with NH listeners, HI listeners have poorer sensitivity to spatial cues, perform more poorly on the selective attention task, and show weaker neural suppression of competing sounds. Moreover, these different measures are correlated both for HI and for NH listeners. These results suggest that poor spatial acuity produces problems with selective attention. These findings have implications both for basic science and for development of next-generation hearing aids. Listeners with sensorineural hearing loss often have trouble understanding speech amid other voices. While poor spatial hearing is often implicated, direct evidence is weak; moreover, studies suggest that reduced audibility and degraded spectrotemporal coding may explain such problems. We hypothesized that poor spatial acuity leads to difficulty deploying selective attention, which normally filters out distracting sounds. In listeners with normal hearing, selective attention causes changes in the neural responses evoked by competing sounds, which can be used to quantify the effectiveness of attentional control. Here, we used behavior and electroencephalography to explore whether control of selective auditory attention is degraded in hearing-impaired (HI) listeners. Normal-hearing (NH) and HI listeners identified a simple melody presented simultaneously with two competing melodies, each simulated from different lateral angles. We quantified performance and attentional modulation of cortical responses evoked by these competing streams. Compared with NH listeners, HI listeners had poorer sensitivity to spatial cues, performed more poorly on the selective attention task, and showed less robust attentional modulation of cortical responses. Moreover, across NH and HI individuals, these measures were correlated. While both groups showed cortical suppression of distracting streams, this modulation was weaker in HI listeners, especially when attending to a target at midline, surrounded by competing streams. These findings suggest that hearing loss interferes with the ability to filter out sound sources based on location, contributing to communication difficulties in social situations. These findings also have implications for technologies aiming to use neural signals to guide hearing aid processing.
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影响因子：
2.8
作者：
Choi, Inyong;Wang, Le;Bharadwaj, Hari;Shinn-Cunningham, Barbara
通讯作者：
Shinn-Cunningham, Barbara
DOI：
10.1007/s10162-008-0146-7
发表时间：
2009-03-01
影响因子：
2.4
作者：
Best, Virginia;Marrone, Nicole;Shinn-Cunningham, Barbara G.
通讯作者：
Shinn-Cunningham, Barbara G.
影响因子：
34.7
作者：
Bizley, Jennifer K.;Cohen, Yale E.
通讯作者：
Cohen, Yale E.
影响因子：
4.3
作者：
Lee AK;Rajaram S;Xia J;Bharadwaj H;Larson E;Hämäläinen MS;Shinn-Cunningham BG
通讯作者：
Shinn-Cunningham BG
DOI：
10.1044/1092-4388(2001/002
发表时间：
2001-02-01
影响因子：
2.6
作者：
Mackersie, CL;Prida, TL;Stiles, D
通讯作者：
Stiles, D