Self-related processing and future thinking: Distinct contributions of ventromedial prefrontal cortex and the medial temporal lobes.
Self-related processing and future thinking: Distinct contributions of ventromedial prefrontal cortex and the medial temporal lobes.
复制标题
自我相关处理和未来思维：腹内侧前额叶皮层和内侧颞叶的独特贡献。
DOI：
10.1016/j.cortex.2019.01.028
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发表时间：
2019
期刊：
影响因子：
--
通讯作者：
Keane,MargaretM
中科院分区：
文献类型：
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作者：
Verfaellie,Mieke;Wank,AubreyA;Reid,AllisonG;Race,Elizabeth;Keane,MargaretM
情景未来思维依赖于一个核心区域网络，除了内侧颞叶（MTL）外，还包括腹内侧前额叶皮层（vmPFC）。神经影像学研究表明，当未来思维需要考虑自我相关信息时，vmPFC特别参与，但vmPFC在构建自我相关情景中的特殊作用的病变证据有限。为了阐明vmPFC在未来思考中的作用，研究人员要求8名vmPFC病变患者想象与自己或他人有关的未来事件，并将他们的表现与8名MTL病变患者的表现进行对比。vmPFC病变患者在描述与自己有关的未来事件时并不比描述与他人有关的事件更详细。相比之下，与对照组一样，MTL病变患者表现出自我利益，尽管总体表现不佳。这些发现与神经影像学研究的证据一致，并阐明了vmPFC和MTL对未来思维的独特贡献。
Episodic future thinking depends on a core network of regions that involves, in addition to the medial temporal lobes (MTL), the ventromedial prefrontal cortex (vmPFC). Neuroimaging studies suggest that vmPFC is particularly involved when future thinking requires consideration of self-relevant information, but lesion evidence for a special role of vmPFC in constructing self-relevant scenarios is limited. To clarify the involvement of vmPFC in future thinking, eight patients with vmPFC lesions were asked to imagine future events pertaining to the self or to another person, and their performance was contrasted with that of eight patients with MTL lesions. Patients with vmPFC lesions were no more detailed in their description of future events pertaining to the self than of events pertaining to another person. In contrast, like controls, patients with MTL lesions showed a self-benefit, despite impoverished performance overall. These findings accord with evidence from neuroimaging studies and elucidate the distinct contributions of vmPFC and MTL to future thinking.