Progress report on studies of FAM-CF for gastric cancer and intraperitoneal administration of FUra-CF followed by cisplatin (DDP).
Progress report on studies of FAM-CF for gastric cancer and intraperitoneal administration of FUra-CF followed by cisplatin (DDP).
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FAM-CF 治疗胃癌和 FUra-CF 腹腔注射顺铂 (DDP) 的研究进展报告。
DOI：
10.1007/978-1-4684-5607-3_31
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发表时间：
1988
影响因子：
--
通讯作者：
Rustum,YM
中科院分区：
文献类型：
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作者：
Arbuck,SG;DouglassJr,HO;Nava,HR;Silk,YN;Baroni,M;Rustum,YM
随机对照试验表明，在结直肠癌患者中，5-氟尿嘧啶(Fura)联合亚叶酸钙(CF)的有效率约为单药Fura的两倍(1-5)。由于FURA单独在其他胃肠道癌症中具有活性，我们的工作一直致力于评估这种联合使用静脉(IV)和腹膜(IP)途径治疗其他胃肠道癌症的作用。
Randomized controlled trials have demonstrated that the response rate to 5-fluorouracil (FUra) in combination with leucovorin (CF) is approximately two-fold higher than the response rate to single agent FUra in patients with colorectal carcinoma (1–5). Since FUra alone has activity in other gastrointestinal cancers, our work has been directed toward evaluating the role of this combination for the treatment of other gastrointestinal cancers, using both the intravenous (IV) and intraperitoneal (IP) routes.