A case of Weber-Christian disease with collapsing glomerulopathy.
A case of Weber-Christian disease with collapsing glomerulopathy.
复制标题
韦伯-克里斯蒂安病伴塌陷性肾小球病一例。
DOI：
10.1053/j.ajkd.2006.05.025
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发表时间：
2006
期刊：
影响因子：
--
通讯作者：
Jaimes,EdgarA
中科院分区：
文献类型：
--
作者：
Nahar,Nilay;Pardo,Victoriano;Sadhu,Sanghamitra;Young,Larry;Gonzalez,Nora;Jaimes,EdgarA
我们报告一个经皮肤活检证实的韦伯-克里斯蒂安病的病例，患者表现为塌陷性肾小球病和脂肪性间质性肾炎。在肾活检中，肾小球内脏上皮细胞、肾小管细胞和间质巨噬细胞装载有形态学上与氧化脂蛋白一致的内含物，表明脂膜炎衍生的脂质可能具有致病作用。
We report a case of Weber-Christian disease confirmed by skin biopsy in a patient who presented with collapsing glomerulopathy and lipophagic interstitial nephritis. On renal biopsy, glomerular visceral epithelial cells, tubular cells, and interstitial macrophages were loaded with inclusions that were morphologically consistent with oxidized lipoproteins, suggesting that lipids derived from the panniculitis may have an etiopathogenic role.