Survival changes in patients with small cell lung cancer and disparities between different sexes, socioeconomic statuses and ages.
Survival changes in patients with small cell lung cancer and disparities between different sexes, socioeconomic statuses and ages.
复制标题
小细胞肺癌患者的生存变化以及不同性别、社会经济地位和年龄之间的差异
DOI：
10.1038/s41598-017-01571-0
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发表时间：
2017-05-02
影响因子：
4.6
通讯作者：
Sun H
中科院分区：
文献类型：
--
作者：
Wang S;Tang J;Sun T;Zheng X;Li J;Sun H;Zhou X;Zhou C;Zhang H;Cheng Z;Ma H;Sun H
小细胞肺癌（SCLC）仅占肺癌病例的15-17%。SCLC治疗的发展几十年来一直停滞不前，预计SCLC将持续威胁人类健康。迄今为止，尚未报告基于大量人群的出版物。我们根据监测、流行病学和最终结果（SEER）登记研究，计算了1983年至2012年每十年SCLC患者的生存变化，以确定种族、性别、年龄和社会经济地位（SES）对生存率的作用。总共确定了106，296例SCLC患者，每10万人的总发病率每十年从9.6降至7.8再降至5.8。SCLC的中位生存期为7个月，12个月相对生存率（RSRs）在每10年中保持相对稳定，分别为32.9%、33.2%和33.2%。在每10年期间，5年RSRs从4.9%显著改善至5.9%再至6.4%，但仍然极低。此外，观察到社会经济地位群体之间的生存差距缩小，性别之间的生存差距稳定。尽管SCLC的发病率在每十年都有所下降，但总体生存率保持相对稳定，这突出了开发新治疗方法的紧迫性以及预防和早期发现的重要性。
Small cell lung cancer (SCLC), as a proportion, makes up only 15–17% of lung cancer cases. The development of treatments for SCLC has remained stagnant for decades, and SCLC is expected to persist as a threat to human health. To date, no publications based on large populations have been reported. We calculated survival changes in patients with SCLC during each decade between 1983 and 2012 to determine the roles of race, sex, age, and socioeconomic status (SES) on survival rates based on the Surveillance, Epidemiology, and End Results (SEER) registries. In total, 106,296 patients with SCLC were identified, with the overall incidence per 100,000 decreasing each decade from 9.6 to 7.8 to 5.8. The median survival for SCLC remained 7 months, and the 12-month relative survival rates (RSRs) remained relatively stable at 32.9%, 33.2% and 33.2% during each decade. The 5-year RSRs significantly improved from 4.9% to 5.9% to 6.4% during each decade, but remained extremely low. In addition, a narrowing of the survival gaps among SES groups and stable survival gaps between sexes were observed. Although the incidence of SCLC decreased during each decade, the overall survival remained relatively stable, highlighting the urgency of developing novel treatments and the importance of prevention and early detection.