Nocturia Frequency, Bother, and Quality of Life: How Often Is Too Often? A Population-Based Study in Finland
Nocturia Frequency, Bother, and Quality of Life: How Often Is Too Often? A Population-Based Study in Finland
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DOI：
10.1016/j.eururo.2009.03.080
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发表时间：
2010-03-01
期刊：
影响因子：
23.4
通讯作者：
Auvinen, Anssi
中科院分区：
文献类型：
--
作者：
Tikkinen, Kari A. O.;Johnson, Theodore M., II;Auvinen, Anssi
背景：夜尿症（即夜间醒来排尿）很常见，会扰乱睡眠。传统上，一个夜间发作被认为是临床上没有意义的，但这种信念的理由仍然weak.Objective：为了评估之间的关联频率的失眠和困扰和健康相关的生活质量（HRQoL）。设计，设置和参与者：在2003-2004年，一项调查被邮寄到一个随机抽样的6000名受试者，年龄在18-79岁之间，他们是从芬兰人口登记中心确定的（应答比例为62.4%; 53.7%为女性）。测量：HRQoL和来自排尿的困扰与自我报告的排尿频率相关（使用美国泌尿外科协会症状指数和丹麦前列腺症状评分）。根据四分量表（无、轻微、中度、严重）评估了来自呼吸困难的困扰。HRQoL采用通用15 D量表，以0-1为标准进行测量，最小临床意义差值为0.03。结果与局限性：患者的烦恼程度随发作频率的增加而增加（P < 0.01）。对于那些有一次、两次和三次夜间排尿的人来说，最常见的困扰程度分别是无困扰、小困扰和中度困扰。无尿失禁的男性（和女性）的平均年龄调整15 D评分为0.953（0.950）和0.925（0.927），每晚一次排尿，0.898（0.890）每晚两次排尿，0.833（0.840）每晚三次或更多排尿。除进食外，15 D评分和所有15 D维度均出现统计学显著性下降。虽然响应率很高，约三分之一的接触没有参加研究。结论：至少有两个空隙，每晚与受损的HRQoL。大多数人报告说，当失眠发作次数为两次时，他们会感到困扰，当次数为三次或三次以上时，他们会感到中度或重度困扰。每晚一次排尿不能识别受试者是否受到排尿干扰，因此，不是临床相关排尿的合适标准。(C)2009年欧洲泌尿外科协会。由Elsevier B出版。V.保留所有权利。
Background: Nocturia (ie, waking at night to void) is common and disrupts sleep. Traditionally, one nightly episode has been regarded as clinically meaningless, yet the justification for this belief remains weak.Objective: To evaluate the association among frequency of nocturia and bother and health-related quality of life (HRQoL).Design, setting, and participants: In 2003-2004, a survey was mailed to a random sample of 6000 subjects aged 18-79 yr who were identified from the Finnish Population Register Centre ( response proportion was 62.4%; 53.7% were females).Measurements: HRQoL and bother from nocturia were examined in relation to self-reported nocturia frequency ( using the American Urological Association Symptom Index and the Danish Prostatic Symptom Score). Bother from nocturia was assessed on a four-point scale ( none, small, moderate, major). HRQoL was measured with the generic 15D instrument on a 0-1 scale with a minimum clinically important difference of 0.03.Results and limitations: Degree of bother increased with nocturia frequency ( p < 0.01). The most commonly cited degree of bother for those with one, two, and three nightly voids was no bother, small bother, and moderate bother, respectively. The mean age-adjusted 15D score for men ( and women) without nocturia was 0.953 (0.950) and 0.925 (0.927) with one void per night, 0.898 (0.890) with two voids per night, and 0.833 (0.840) with three or more voids per night. Statistically significant decreases were found in 15D score and in all 15D dimensions except eating. Although the response rate was high, approximately one third of those contacted did not participate in the study.Conclusions: At least two voids per night is associated with impaired HRQoL. The majority of people report having bother when the number of nocturia episodes is two and moderate or major bother when the number is three or more. One void per night does not identify subjects with interference from nocturia and, thus, is not a suitable criterion for clinically relevant nocturia. (C) 2009 European Association of Urology. Published by Elsevier B. V. All rights reserved.