Simultaneously extracting multiple parameters via multi-distance and multi-exposure diffuse speckle contrast analysis.
Simultaneously extracting multiple parameters via multi-distance and multi-exposure diffuse speckle contrast analysis.
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DOI：
10.1364/boe.8.004537
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发表时间：
2017-10
影响因子：
3.4
通讯作者：
Jialin Liu;Hongchao Zhang;Jian Lu;X. Ni;Z. Shen
中科院分区：
文献类型：
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作者：
Jialin Liu;Hongchao Zhang;Jian Lu;X. Ni;Z. Shen
扩散散斑对比分析 (DSCA) 的最新进展为无创采集深层组织微血管血流开辟了道路。事实上，除了血流指数 αDB 之外，组织光吸收 μa 的变化、降低的散射系数[公式：见正文]以及相干因子 β 都可以调节散斑图案的时间波动。在本研究中，我们使用多距离和多次曝光 DSCA (MDME-DSCA) 同时提取 μa 、[公式：见正文]、αDB 和 β 等多个参数。通过模拟数据和体模实验验证了MDME-DSCA的有效性。此外，作为比较，结果还表明通过多次曝光DSCA（ME-DSCA）同时获得多个参数是不切实际的。
Recent advancements in diffuse speckle contrast analysis (DSCA) have opened the path for noninvasive acquisition of deep tissue microvasculature blood flow. In fact, in addition to blood flow index αDB , the variations of tissue optical absorption μa , reduced scattering coefficients [Formula: see text], as well as coherence factor β can modulate temporal fluctuations of speckle patterns. In this study, we use multi-distance and multi-exposure DSCA (MDME-DSCA) to simultaneously extract multiple parameters such as μa , [Formula: see text], αDB , and β. The validity of MDME-DSCA has been validated by the simulated data and phantoms experiments. Moreover, as a comparison, the results also show that it is impractical to simultaneously obtain multiple parameters by multi-exposure DSCA (ME-DSCA).