Minocycline HCl microspheres reduce red-complex bacteria in periodontal disease therapy
Minocycline HCl microspheres reduce red-complex bacteria in periodontal disease therapy
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DOI：
10.1902/jop.2007.060488
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发表时间：
2007-08-01
影响因子：
4.3
通讯作者：
Comiskey, Judy
中科院分区：
文献类型：
--
作者：
Goodson, J. Max;Gunsolley, John C.;Comiskey, Judy
背景资料：本试验的目的是测量盐酸米诺环素微球（MM）局部给药系统作为洁治和根面平整（SRP）辅助治疗时的抗菌效果。方法：随机将127例中晚期慢性牙周炎患者分为单纯SRP组（N = 65）和MM + SRP组（N = 62）。本研究的主要终点是红色复合菌（RCB）数量和比例的变化以及牙龈卟啉单胞菌（Porphyromonas gingivalis）、Tannerella gingthia（正式名称为T。在每个测试部位，从基线到第30天，相对于40种口腔细菌，结果：MM + SRP使RCB的比例减少了6.49%，数量减少了9.4 × 10（5）。仅通过SRP减少RCB比例和数量（分别为5.03%和5.1 × 10（5））显著减少。此外，MM + SRP使探针深度减少了1.38 mm（与单独SRP的1.01 mm相比），探诊出血减少了25.2%（与单独SRP的13.8%相比），临床附着水平增加1.16 mm（与单独SRP的0.80 mm相比）。这些观察结果支持这样的假设，即RCB是牙周病的原因，使用MM +的局部抗菌治疗与单独实施SRP相比，SRP更有效地减少了区域协调机构的数量及其比例。
Background: The objective of this trial was to measure the antimicrobial effects of a minocycline HCl microsphere (MM) local drug-delivery system when used as an adjunct to scaling and root planing (SRP). DNA probe analysis for 40 bacteria was used to evaluate the oral bacteria of 127 subjects with moderate to advanced chronic periodontitis.Methods: Subjects were randomly assigned to either SRP alone (N = 65) or MM + SRP (N = 62). The primary endpoints of this study were changes in numbers and proportions of the red-complex bacteria (RCB) and the sum of Porphyromonas gingivalis, Tannerella forsythia (formally T. forsythensis), and Treponema denticola relative to 40 oral bacteria at each test site from baseline to day 30. Numbers of RCB from the five test sites were averaged to provide a value for each subject.Results: MM + SRP reduced the proportion of RCB by 6.49% and the numbers by 9.4 x 10(5). The reduction in RCB proportions and numbers by SRP alone (5.03% and 5.1 X 10(5), respectively) was significantly less. In addition, MM + SRP reduced probing depth by 1.38 mm (compared to 1.01 mm by SRP alone), bleeding on probing was reduced by 25.2% (compared to 13.8% by SRP alone), and a clinical attachment level gain of 1.16 mm (compared to 0.80 mm by SRP alone) was achieved.Conclusion: These observations support the hypothesis that RCBs are responsible for periodontal disease and that local antimicrobial therapy using MM + SRP effectively reduces numbers of RCBs and their proportions to a greater extent than SRP alone.