Memory extinction, learning anew, and learning the new: Dissociations in the molecular machinery of learning in cortex
Memory extinction, learning anew, and learning the new: Dissociations in the molecular machinery of learning in cortex
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DOI：
10.1126/science.1058165
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发表时间：
2001-03-23
期刊：
影响因子：
56.9
通讯作者：
Dudai, Y
中科院分区：
文献类型：
--
作者：
Berman, DE;Dudai, Y
大鼠岛叶皮质(IC)辅助条件性味觉厌恶(CTA)的记忆，在CTA中，味觉与不适有关。当条件味觉陌生时，长期CTA记忆的形成依赖于M受体和β-肾上腺素能受体、丝裂原活化蛋白激酶(MAPK)和蛋白质合成。我们发现，CTA记忆的消退也依赖于IC中的蛋白质合成和β-肾上腺素能受体，但不依赖于M受体和MAPK。这类似于CTA对熟悉的味道形成长期记忆的分子特征。因此，记忆消退与学习有着相同的分子机制，但重新学习的机制与学习新的机制不同。
The rat insular cortex (IC) subserves the memory of conditioned taste aversion (CTA), in which a taste is associated with malaise. When the conditioned taste is unfamiliar, formation of Long-term CTA memory depends on muscarinic and beta -adrenergic receptors, mitogen-activated protein kinase (MAPK), and protein synthesis. We show that extinction of CTA memory is also dependent on protein synthesis and beta -adrenergic receptors in the IC, but independent of muscarinic receptors and MAPK. This resembles the molecular signature of the formation of Long-term memory of CTA to a familiar taste. Thus, memory extinction shares molecular mechanisms with Learning, but the mechanisms of learning anew differ from those of Learning the new.