Alternative Splicing in Breast Cancer and the Potential Development of Therapeutic Tools.
Alternative Splicing in Breast Cancer and the Potential Development of Therapeutic Tools.
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DOI：
10.3390/genes8100217
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发表时间：
2017-10-05
期刊：
影响因子：
3.5
通讯作者：
Martínez-Contreras RD
中科院分区：
文献类型：
--
作者：
Martínez-Montiel N;Anaya-Ruiz M;Pérez-Santos M;Martínez-Contreras RD
选择性剪接是一种关键的分子机制，现在被认为是癌症的一个标志，在疾病的发病和进展过程中，它与不同亚型的表达有关。全世界妇女癌症相关死亡的主要原因是乳腺癌，即使已经确定了选择性剪接在这类癌症中的作用，这种机制在乳腺癌生物学中的功能也没有完全解码。为了全面了解选择性剪接在乳腺癌生物学和发展中的作用，考虑到其预后和治疗价值，我们总结了最近关于选择性剪接事件的发现，这些事件在乳腺癌的进化中得到了很好的记录。此外，我们分析了对内分泌和化学治疗的反应如何受到可变剪接和变异亚型差异表达的影响。有了这些知识，很明显，靶向选择性剪接代表了乳腺癌治疗的一种创新方法，从当前研究中获得的信息可以指导临床决策，直接影响当今乳腺癌患者的临床进展。
Alternative splicing is a key molecular mechanism now considered as a hallmark of cancer that has been associated with the expression of distinct isoforms during the onset and progression of the disease. The leading cause of cancer-related deaths in women worldwide is breast cancer, and even when the role of alternative splicing in this type of cancer has been established, the function of this mechanism in breast cancer biology is not completely decoded. In order to gain a comprehensive view of the role of alternative splicing in breast cancer biology and development, we summarize here recent findings regarding alternative splicing events that have been well documented for breast cancer evolution, considering its prognostic and therapeutic value. Moreover, we analyze how the response to endocrine and chemical therapies could be affected due to alternative splicing and differential expression of variant isoforms. With all this knowledge, it becomes clear that targeting alternative splicing represents an innovative approach for breast cancer therapeutics and the information derived from current studies could guide clinical decisions with a direct impact in the clinical advances for breast cancer patients nowadays.
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影响因子：
4
作者：
Aylon, Yael;Oren, Moshe
通讯作者：
Oren, Moshe
影响因子：
168.9
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影响因子：
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Brufsky A
影响因子：
3.6
作者：
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Raez, Luis Estuardo
影响因子：
16
作者：
Anczuków O;Akerman M;Cléry A;Wu J;Shen C;Shirole NH;Raimer A;Sun S;Jensen MA;Hua Y;Allain FH;Krainer AR
通讯作者：
Krainer AR