Multicomponent-assembled nanodiamond hybrids for targeted and imaging guided triple-negative breast cancer therapy via a ternary collaborative strategy
Multicomponent-assembled nanodiamond hybrids for targeted and imaging guided triple-negative breast cancer therapy via a ternary collaborative strategy
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多组分组装纳米金刚石混合物通过三元协作策略用于靶向和成像引导的三阴性乳腺癌治疗
DOI：
10.1039/d1bm00283j
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发表时间：
2021-04-15
影响因子：
6.6
通讯作者：
Sheng, Wang
中科院分区：
文献类型：
--
作者：
Cui, Xinyue;Deng, Xiongwei;Sheng, Wang
联合联合策略已被证实是高性能癌症治疗的有力选择，因为它们能够克服肿瘤的异质性和复杂性。然而，开发一种简单、有效、多功能的治疗纳米平台仍然是一个挑战。在这项研究中，我们基于疏水和静电非共价相互作用的组合，将多组分透明质酸(HA)、鱼精蛋白(PS)、纳米钻石(NDS)、姜黄素(CUR)和IR780集成到单个纳米平台(记为HPNDIC)中，用于双模式荧光/光声成像引导的三元协同CUR/光热/光动力学联合治疗三阴性乳腺癌(TNBC)。为了实现这一目的，采用了两步协调装配策略。第一步，利用PS修饰NDS团簇，形成带正电荷的PS@NDS(PND)，同时包裹天然小分子药物Cur和光敏小分子IR780(PNDIC)。其次，通过电荷络合将HA吸附到PNDIC的外表面，赋予其肿瘤靶向能力(HPNDIC)。所制得的HPNDIC具有均匀的尺寸、高的载药能力和良好的胶体稳定性。研究发现，在近红外线照射条件下，IR780可被触发表现出PTT/PDT双重治疗效应，导致体内和体外CUR治疗效率的提高，并具有良好的生物相容性。由于IR780的固有成像特性，HPNDIC在体内的生物分布和蓄积行为可通过双模式荧光/光声成像进行监测。综上所述，我们目前的工作展示了一种基于NDS的多组分治疗平台的组装，用于双模式荧光/光声成像引导的三重协作CUR/光热/光动力学对抗TNBC。
Uniting combinational strategies has been confirmed to be a robust choice for high-performance cancer treatment due to their abilities to overcome tumor heterogeneity and complexity. However, the development of a simple, effective, and multifunctional theranostics nanoplatform still remains a challenge. In this study, we integrated multicomponent hyaluronic acid (HA), protamine (PS), nanodiamonds (NDs), curcumin (Cur), and IR780 into a single nanoplatform (denoted as HPNDIC) based on the combination of hydrophobic and electrostatic noncovalent interactions for dual-modal fluorescence/photoacoustic imaging guided ternary collaborative Cur/photothermal/photodynamic combination therapy of triple-negative breast cancer (TNBC). A two-step coordination assembly strategy was utilized to realize this purpose. In the first step, PS was utilized to modify the NDs clusters to form positively charged PS@NDs (PND) and the simultaneous encapsulation of the natural small-molecule drug Cur and the photosensitive small-molecule IR780 (PNDIC). Second, HA was adsorbed onto the outer surface of the PNDIC through charge complexation for endowing a tumor-targeting ability (HPNDIC). The resulting HPNDIC had a uniform size, high drug-loading ability, and excellent colloidal stability. It was found that under the near-infrared irradiation condition, IR780 could be triggered to exhibit both PTT/PDT dual-pattern therapy effects, leading to an enhanced therapy efficiency of Cur both in vitro and in vivo with good biocompatibility. Due to the intrinsic imaging property of IR780, the biodistribution and accumulation behavior of HPNDIC in vivo could be monitored by dual-modal fluorescence/photoacoustic imaging. Taken together, our current work demonstrated the assembly of a NDs-based multicomponent theranostic platform for dual-modal fluorescence/photoacoustic imaging guided triple-collaborative Cur/photothermal/photodynamic against TNBC.