CIGARETTE-SMOKING AND THE RISK OF ANOGENITAL CANCER
CIGARETTE-SMOKING AND THE RISK OF ANOGENITAL CANCER
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DOI：
10.1093/oxfordjournals.aje.a116270
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发表时间：
1992-01-15
影响因子：
5
通讯作者：
WEISS, NS
中科院分区：
文献类型：
--
作者：
DALING, JR;SHERMAN, KJ;WEISS, NS
吸烟和宫颈癌之间的关联已经在许多先前的研究中得到证实。作为20世纪80年代中期至今在华盛顿州西部和不列颠哥伦比亚省进行的外阴癌、阴道癌、宫颈癌、肛门癌和阴茎癌与人乳头瘤病毒感染相关的人群病例对照研究的一部分，作者收集了吸烟史的详细信息。目前吸烟的受试者比例范围从阴道癌和宫颈癌病例中略高于40%到外阴癌和肛门癌病例中的60%。相比之下，只有约25%的对照组是目前的吸烟者。除阴道癌（OR = 1.3）外，所有癌症部位与当前吸烟相关的校正比值比（OR = 1.9-14.6）均显著升高。吸烟的风险往往与吸烟的数量成比例增加。对于大多数癌症部位，与既往吸烟相关的比值比显著低于与当前吸烟相关的比值比，并且随着戒烟时间的增加而降低。作者的数据和其他研究者的数据表明，吸烟在肛门生殖器癌的病因学中起作用，吸烟具有晚期或促进作用。
The association between cigarette smoking and cervical cancer has been demonstrated in numerous prior studies. As part of population-based case-control studies of cancers of the vulva, vagina, cervix, anus, and penis in relation to infection with human papillomavirus, conducted in western Washington State and the province of British Columbia from the mid 1980s until the present time, the authors have collected detailed information on smoking history. The proportion of subjects who were current smokers of cigarettes ranged from slightly over 40% among incident cases of vaginal and cervical cancer to 60% among cases of vulvar and anal cancer. In contrast, only about 25% of controls were current smokers. The adjusted odds ratios (OR) associated with current smoking were substantially elevated (OR = 1.9-14.6) for all cancer sites except cancer of the vagina (OR = 1.3). The risks tended to increase in proportion to the number of cigarettes smoked. For most cancer sites, the odds ratios associated with former smoking were substantially less than those associated with current smoking and diminished with increasing time since cessation of smoking. The authors' data and those of other investigators suggest that cigarette smoking plays a role in the etiology of anogenital cancers and that smoking has a late-stage or promotional effect.