Standard virtual biological parts: a repository of modular modeling components for synthetic biology
Standard virtual biological parts: a repository of modular modeling components for synthetic biology
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DOI：
10.1093/bioinformatics/btq063
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发表时间：
2010-04-01
期刊：
影响因子：
5.8
通讯作者：
Wipat, A.
中科院分区：
文献类型：
--
作者：
Cooling, M. T.;Rouilly, V.;Wipat, A.
动机：通过结合工程设计原理和技术，如计算机辅助设计，合成生物系统的制造得到了极大的提高。为此，正在进行的生物部件的标准化提供了一个机会，以开发标准的虚拟部件库的形式的数学模型，可以结合起来，通知系统design.Results：我们提出了一个在线的知识库，填充了一个集合的标准化模型，可以很容易地重组到不同的生物系统使用固有的模块化支持的CellML 1.1模型交换格式。这种方法的适用性证明了金牌获奖iGEM机器建模。
Motivation: Fabrication of synthetic biological systems is greatly enhanced by incorporating engineering design principles and techniques such as computer-aided design. To this end, the ongoing standardization of biological parts presents an opportunity to develop libraries of standard virtual parts in the form of mathematical models that can be combined to inform system design.Results: We present an online Repository, populated with a collection of standardized models that can readily be recombined to model different biological systems using the inherent modularity support of the CellML 1.1 model exchange format. The applicability of this approach is demonstrated by modeling gold-medal winning iGEM machines.