High-resolution scintimammography improves the accuracy of technetium-99m methoxyisobutylisonitrile scintimammography: use of a new dedicated gamma camera
High-resolution scintimammography improves the accuracy of technetium-99m methoxyisobutylisonitrile scintimammography: use of a new dedicated gamma camera
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高分辨率闪烁钼靶提高了锝-99m甲氧基异丁基异腈闪烁钼靶的准确性：使用新型专用伽玛相机
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发表时间：
1999
期刊：
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通讯作者：
L. Porfiri
中科院分区：
文献类型：
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作者：
F. Scopinaro;R. Pani;G. de Vincentis;A. Soluri;R. Pellegrini;L. Porfiri
抽象的。99m甲氧基异丁基异腈(MIBI)显像的主要缺点是对小于1厘米的T1a和T1b癌的灵敏度有限。我们基于一个新的概念，即位置敏感的光电倍增管，开发了一种使用伽马相机的高分辨率摄像技术。这款相机以前被称为SPEM(单光子发射乳房X光照相)相机，其视野直径为10厘米。在横断层面上采集乳腺断层图像，每个乳房被压缩至3~6 cm厚，MODEL级为4 cm。当被压缩的乳房大于视野时，为了对整个腺体成像，进行了不止一次的研究。对53例患者进行了高分辨率核素扫描(HRSM)和愤怒相机倾向核素扫描(ACPSM)。静脉注射后70min行HRSM检查。注射99mTC-MIBI 740MBq，分别于注射后10min和60min采集ACPSM图像。早期10min的ACPSM图像仅用于常规诊断目的，而60min的ACPSM图像和70min的HRSM图像进行了比较。细针抽吸(FNA)和/或开腹活检发现癌31例，其中T1c 15例，T1b 11例，T1a 5例。在T1a-T1b癌中，ACPSM和HRSM的灵敏度分别为50%和81.2%(P<；0.01)。两种方法的特异度均为86%。HRSM是一种很有前景的新技术，它可以在不明显降低其特异性的情况下，提高99mTC-MIBI显像对小于1 cm肿瘤的敏感性。我们现在正在研制一种更大视野的相机。
Abstract. The main disadvantage of technetium-99m methoxyisobutylisonitrile (MIBI) prone scintimammography is its limited sensitivity for T1a and T1b cancers with a size of less than 1 cm. We have developed a high-resolution scintimammographic technique using a gamma camera based on a new concept, namely a position-sensitive photo-multiplier tube. The field of view of this camera, previously known as the SPEM (single photon emission mammography) camera, was 10 cm diameter. Scintimammographic images were acquired in the axial view; each breast was compressed to a thickness of 3–6 cm, modal class 4 cm. When the compressed breast was larger than the field of view, more than one study was performed in order to image the entire gland. Fifty-three patients were studied with high-resolution-scintimammography (HRSM) and Anger camera prone scintimammography (ACPSM). HRSM was performed 70 min after i.v. administration of 740 Mbq of 99mTc-MIBI; ACPSM images were acquired 10 and 60 min following the injection. Early 10-min ACPSM images were only evaluated for routine diagnostic purposes, while comparison was carried out between the 60-min ACPSM and 70-min HRSM images. At fine-needle aspiration (FNA) and/or open biopsy, 31 patients showed cancer: 15 T1c, 11 T1b and 5 T1a. In T1a-T1b cancers, the sensitivity of scintimammography was 50% with ACPSM and 81.2% with HRSM (P<0.01). Specificity was 86% with both techniques. HRSM is a promising new technique that improves the sensitivity of 99mTc-MIBI scintimammography in tumours sized less than 1 cm without apparently reducing its specificity. We are now working on a larger field-of-view camera.