Effects of exercise training on glucose control, lipid metabolism, and insulin sensitivity in hypertriglyceridemia and non-insulin dependent diabetes mellitus.
Effects of exercise training on glucose control, lipid metabolism, and insulin sensitivity in hypertriglyceridemia and non-insulin dependent diabetes mellitus.
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运动训练对高甘油三酯血症和非胰岛素依赖型糖尿病的血糖控制、脂质代谢和胰岛素敏感性的影响。
DOI：
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发表时间：
1991
影响因子：
4.1
通讯作者：
David E. Schteingart
中科院分区：
文献类型：
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作者：
Richard M. Lampman;David E. Schteingart
运动训练对高脂血症和/或非胰岛素依赖型糖尿病患者具有潜在的益处。在患有高甘油三酯血症的非糖尿病、非肥胖受试者中，单独的运动训练可以增加胰岛素敏感性，改善葡萄糖耐量，并降低血清甘油三酯和胆固醇水平。当类似的糖耐量受损患者仅进行运动训练时，这些改善并未发生。在没有糖尿病的严重肥胖（X = 125 kg）受试者中，仅 600 卡路里饮食即可降低葡萄糖和胰岛素浓度并改善葡萄糖耐量，但不会增加胰岛素敏感性。运动训练的加入提高了胰岛素敏感性。肥胖、非胰岛素依赖型糖尿病受试者单独接受磺酰脲类治疗可增加胰岛素水平，但未能改善胰岛素敏感性或血糖水平。相比之下，在这种药物的基础上添加运动训练可以提高胰岛素敏感性并降低血糖水平。我们的结论是，运动训练对降低高脂血症受试者的甘油三酯水平具有重要作用，并且可以增强饮食或药物治疗对非胰岛素依赖型糖尿病患者葡萄糖代谢的影响。
Exercise training has potential benefits for patients with hyperlipidemia and/or non-insulin dependent diabetes mellitus. In nondiabetic, nonobese subjects with hypertriglyceridemia, exercise training alone increased insulin sensitivity, improved glucose tolerance, and lowered serum triglyceride and cholesterol levels. These improvements did not occur when exercise training alone was given to similar patients with impaired glucose tolerance. In severely obese (X = 125 kg) subjects without diabetes melitus, a 600 calorie diet alone decreased glucose and insulin concentrations and improved glucose tolerance but did not increase insulin sensitivity. The addition of exercise training improved insulin sensitivity. Obese, non-insulin dependent diabetes mellitus subjects on sulfonylurea therapy alone increased insulin levels but failed to improve insulin sensitivity or glucose levels. In contrast, the addition of exercise training to this medication resulted in improved insulin sensitivity and lowered glucose levels. We conclude that exercise training has major effects on lowering triglyceride levels in hyperlipidemic subjects and can potentiate the effect of diet or drug therapy on glucose metabolism in patients with non-insulin dependent diabetes mellitus.