FREE-RADICALS IN AGING
FREE-RADICALS IN AGING
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DOI：
10.1007/bf00421050
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发表时间：
1988-12-01
影响因子：
4.3
通讯作者：
HARMAN, D
中科院分区：
文献类型：
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作者：
HARMAN, D
衰老是随着时间的推移而逐渐积累的变化，这些变化导致疾病和死亡的可能性不断增加。这些不可逆转的变化归因于衰老过程。这个过程现在是发达国家的主要死亡原因。这一事实被这个过程对终止生命的事件所起的作用的千变万化的性质所掩盖。衰老过程可能是由于自由基反应。这一理论得到以下方面的支持：（1）关于生命起源和进化的研究;（2）关于电离辐射对生命系统影响的大量研究;（3）改变饮食以改变内源性自由基反应水平的寿命实验;（4）对衰老现象的合理解释;（五）越来越多的研究表明，自由基反应与特定疾病的发病机制有关。衰老与涉及自由基反应的疾病之间的关系似乎是一个直接一。个体之间的遗传和环境差异对有害自由基反应诱导的变化在整个身体中的正常分布的调节导致变化模式，在某些情况下，与正常衰老模式完全不同，从而被认为是疾病。越来越多的“自由基”疾病包括两个主要的死亡原因，癌症和动脉粥样硬化。根据目前的数据，合理选择饮食和抗氧化剂补充剂将使健康，活跃的寿命延长5-10年或更长。
Aging is the progressive accumulation of changes with time that are responsible for the ever-increasing likelihood of disease and death. These irreversible changes are attributed to the aging process. This process is now the major cause of death in the developed countries. This fact is obscured by the protean nature of the contributions of this process to the events which terminate life.The aging process may be due to free radical reations. This theory is supported by: 1) studies on the origin and evolution of life; 2) the numerous studies of the effect of ionizing radiation on living systems; 3) life span experiments in which the diet was modified so as to alter endogenous free radical reaction levels; 4) the plausible explanations it provides for aging phenomena; and 5) the growing number of studies which implicate free radical reactions in the pathogenesis of specific diseases.The relationship between aging and diseases involving free radical reactions seems to be a direct one. Modulation of the normal distribution of deleterious free radical reaction-induced changes throughout the body by genetic and environmental differences between individuals results in patterns of change, in some sufficiently different from the normal aging pattern to be recognized as disease. The growing number of ‘free radical’ diseases includes the two major causes of death, cancer and atherosclerosis.It is reasonable to expect on the basis of present data that a judicious selection of diets and antioxidant supplements will increase the healthy, active life span by 5–10 or more years.