Relationship Between Interleukin-10 Gene C-819T Polymorphism and Gastric Cancer Risk: Insights From a Meta-Analysis.
Relationship Between Interleukin-10 Gene C-819T Polymorphism and Gastric Cancer Risk: Insights From a Meta-Analysis.
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DOI：
10.12659/msm.895333
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发表时间：
2016-08-12
期刊：
影响因子：
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通讯作者：
Tian G
中科院分区：
文献类型：
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作者：
Cui X;Huang Q;Li X;Liu F;Wang D;Yan D;Wang B;Yang C;Mi J;Tian G
白细胞介素-10 （interleukin-10, IL-10）是一种多效性细胞因子，在癌变和肿瘤生长中起调节作用。本荟萃分析的目的是评估IL-10基因C-819T多态性对胃癌的易感性。研究鉴定和数据提取由2位作者独立完成。计算并总结优势比（OR）和95%置信区间（95% CI）。共纳入11篇文献，包括1960例胃癌患者和3705例对照。总体分析显示，与−819C等位基因相比，−819T等位基因导致的胃癌风险降低13% (OR=0.87; 95% CI: 0.77-0.97； P=0.016)，无异质性（I2=35.1%）。在亚组分析中，东亚人群（OR=0.85; 95% CI: 0.73-0.98； P=0.029, I2=43.6%）、胃腺癌（OR=0.80; 95% CI: 0.66-0.96； P=0.017, I2=0.0%）和基于人群的研究（OR=0.81; 95% CI: 0.70-0.93； P=0.003, I2=0.0%）中发现了显著差异。视觉漏斗图和Egger的检验没有显示出发表偏倚的证据。在之前研究的基础上，我们证实IL-10基因- 819T等位基因在胃癌易感性中具有保护作用，并且这种作用在胃腺癌中更为明显。
As a pleiotropic cytokine, interleukin-10 (IL-10) plays a regulatory role in carcinogenesis and tumor growth. The aim of this meta-analysis was to assess the susceptibility of the IL-10 gene C-819T polymorphism to gastric cancer. Study identification and data extraction were independently completed by 2 authors. Odds ratios (OR) and 95% confidence intervals (95% CI) were calculated and summarized. In total, 11 articles including 1960 gastric cancer patients and 3705 controls were qualified. Overall analyses revealed a 13% reduced risk of gastric cancer conferred by the −819T allele relative to the −819C allele (OR=0.87; 95% CI: 0.77–0.97; P=0.016), without heterogeneity (I2=35.1%). In subgroup analyses, a significant difference was identified in East Asian populations (OR=0.85; 95% CI: 0.73–0.98; P=0.029, I2=43.6%), for gastric adenocarcinoma (OR=0.80; 95% CI: 0.66–0.96; P=0.017, I2=0.0%), and in population-based studies (OR=0.81; 95% CI: 0.70–0.93; P=0.003, I2=0.0%). The visual funnel plots and Egger’s tests suggested no evidence of publication bias. Extending previous findings, we demonstrate a protective role of the IL-10 gene −819T allele in susceptibility to gastric cancer, and this role was more evident for gastric adenocarcinoma.