Protective effect of pregnancy for development of uterine leiomyoma
Protective effect of pregnancy for development of uterine leiomyoma
复制标题
DOI：
10.1093/carcin/22.12.2049
复制
发表时间：
2001-12-01
期刊：
影响因子：
4.7
通讯作者：
Davis, B
中科院分区：
文献类型：
--
作者：
Walker, CL;Cesen-Cummings, K;Davis, B
已经确定了许多可以调节子宫肌瘤发生风险的因素，包括产次。关于降低患这种疾病的风险的流行病学数据，对于怀孕本身是否具有保护作用，或者由于平滑肌瘤是不孕的主要原因，患上这些肿瘤的女性生育能力较低，因此怀孕率较低，存在不同的解释。我们利用遗传上易患子宫肌瘤的动物模型来研究怀孕对患这种疾病的风险的潜在保护作用。携带结节性硬化症 2 (Tsc-2) 肿瘤抑制基因突变的雌性 Eker 大鼠在未产时发生子宫肌瘤的概率为 65%。这些动物与完整或输精管切除的雄性饲养，并在动物一生中单次妊娠（以确认生育能力）或多次妊娠后确定肿瘤发病率。多窝雌性在肿瘤发生率和表现方面表现出巨大的变化。肿瘤发生率从单窝雌性的 71% 降至多窝雌性（平均：每只动物 5 窝）的 10%。有趣的是，与切除输精管的雄性交配的雌性也表现出肿瘤发病率降低了 41%，这表明假孕雌性中发生的与怀孕早期相关的激素变化可能有助于怀孕的保护作用。
Many factors that can modulate the risk of developing uterine leiomyoma have been identified, including parity. Epidemiological data on decreased risk of developing this disease has been subject to different interpretations regarding whether pregnancy per se is protective or, as leiomyomas are a major cause of infertility, women that develop these tumors are less fertile and thus have lower pregnancy rates. We have utilized an animal model genetically predisposed to uterine leiomyoma to investigate the potential protective effect of pregnancy on the risk of developing this disease. Female Eker rats that carry a mutation in the tuberous sclerosis 2 (Tsc-2) tumor suppressor gene develop uterine leiomyoma with a frequency of 65% when nulliparous. These animals were bred with intact or vasectomized males and tumor incidence determined after a single pregnancy (to confirm fertility) or multiple pregnancies over the lifetime of the animals. Females with multiple litters displayed a dramatic shift in tumor incidence and presentation. Tumor incidence decreased from 71% in single litter females to 10% in females that had multiple litters (average: five litters/animal). Interestingly, females bred with vasectomized males also exhibited a reduced tumor incidence of 41%, suggesting that the hormonal changes associated with early stages of pregnancy that occur in pseudopregnant females may have contributed to the protective effect of pregnancy.