Deficiency of liver-X-receptor-α reduces glucose uptake and worsens post-myocardial infarction remodeling.
Deficiency of liver-X-receptor-α reduces glucose uptake and worsens post-myocardial infarction remodeling.
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肝脏-X-受体-α 的缺乏会减少葡萄糖的摄取并加剧心肌梗死后的重塑。
DOI：
10.1016/j.bbrc.2017.05.072
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发表时间：
2017-07
影响因子：
3.1
通讯作者：
He Ben
中科院分区：
文献类型：
--
作者：
Ji Qingqi;Zhao Yichao;Yuan Ancai;Pu Jun;He Ben
肝X受体α (LXRα)是一种内源性抗缺血性心脏病的保护性受体。然而，LXRα是否调节缺血性心脏病的糖代谢尚未研究。在本研究中，我们研究了LXRα在心肌梗死（MI）后心脏重构过程中对糖代谢的参与。永久性结扎左冠状动脉前降支（LCA）诱导小鼠心肌梗死。遗传性LXRα缺失在心肌梗死后4周显著加重了心脏重塑和心功能受损。正电子发射断层扫描（PET）显示，LXRα−/−小鼠的心脏18f -氟脱氧葡萄糖（FDG）摄取量显著低于WT小鼠。机制上，LXRα−/−小鼠GLUT1/4和AMPK磷酸化显著下调，CD36表达显著上调。该研究表明，LXRα缺乏会降低心肌梗死后的葡萄糖摄取，导致代谢改变，抑制葡萄糖代谢，这与不良的心脏重构有关。
Liver X receptor α (LXRα) is an endogenous protective receptor against ischemic heart diseases. However, whether LXRα regulated glucose metabolism in ischemic heart diseases has not been investigated. In this study we investigated the involvement of LXRα on glucose metabolism in cardiac remodeling after myocardial infarction (MI).MI was induced in mice by permanent ligation of the left anterior descending coronary artery (LCA). Genetic LXRα deletion significantly worsened cardiac remodeling and impaired cardiac function at 4 weeks after MI. Cardiac 18F-fluorodeoxyglucose (FDG) uptake by positron emission tomography (PET) demonstrated that the FDG standardized uptake value (SUV) was significantly lower in LXRα−/−mice as compared to WT mice. Mechanistically, GLUT1/4 and AMPK phosphorylation were significantly downregulated while CD36 expression was markedly upregulated in LXRα−/−mice. This study demonstrated that deficiency of LXRα decreased glucose uptake after MI, resulting in a metabolic shift that suppressed glucose metabolism, which was in association with adverse cardiac remodeling.
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影响因子：
20.1
作者：
Doenst T;Nguyen TD;Abel ED
通讯作者：
Abel ED
肝 X 受体激动剂治疗可减轻 2 型糖尿病 db/db 小鼠的心功能障碍
影响因子：
9.3
作者：
He Q;Pu J;Yuan A;Yao T;Ying X;Zhao Y;Xu L;Tong H;He B
通讯作者：
He B
影响因子：
24
作者：
Pu, Jun;Mintz, Gary S.;Maehara, Akiko
通讯作者：
Maehara, Akiko
影响因子：
11.1
作者：
Cannon MV;Silljé HH;Sijbesma JW;Vreeswijk-Baudoin I;Ciapaite J;van der Sluis B;van Deursen J;Silva GJ;de Windt LJ;Gustafsson JÅ;van der Harst P;van Gilst WH;de Boer RA
通讯作者：
de Boer RA
影响因子：
10.8
作者：
Papageorgiou, Anna-Pia;Heggermont, Ward;Heymans, Stephane
通讯作者：
Heymans, Stephane