Alcohol Consumption, Cigarette Smoking, and Risk of Breast Cancer for BRCA1 and BRCA2 Mutation Carriers: Results from The BRCA1 and BRCA2 Cohort Consortium.
Alcohol Consumption, Cigarette Smoking, and Risk of Breast Cancer for BRCA1 and BRCA2 Mutation Carriers: Results from The BRCA1 and BRCA2 Cohort Consortium.
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DOI：
10.1158/1055-9965.epi-19-0546
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发表时间：
2020-02
期刊：
影响因子：
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通讯作者：
Goldgar DE
中科院分区：
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作者：
Li H;Terry MB;Antoniou AC;Phillips KA;Kast K;Mooij TM;Engel C;Noguès C;Stoppa-Lyonnet D;Lasset C;Berthet P;Mari V;Caron O;GENEPSO study;Barrowdale D;Frost D;Brewer C;Evans DG;Izatt L;Side L;Walker L;Tischkowitz M;Rogers MT;Porteous ME;Snape K;EMBRACE study;Meijers-Heijboer HEJ;Gille JJP;Blok MJ;Hoogerbrugge N;HEBON Investigators;Daly MB;Andrulis IL;Buys SS;John EM;McLachlan SA;Friedlander M;kConFab Investigators;Tan YY;Osorio A;Caldes T;Jakubowska A;Simard J;Singer CF;Olah E;Navratilova M;Foretova L;Gerdes AM;Roos-Blom MJ;Arver B;Olsson H;Schmutzler RK;Hopper JL;Milne RL;Easton DF;Van Leeuwen FE;Rookus MA;Andrieu N;Goldgar DE
吸烟和饮酒已在一般人群中进行了深入研究，以评估其对乳腺癌（BC）风险的影响，但很少有研究在BRCA 1和BRCA 2突变携带者中检查这些影响。鉴于突变携带者的高BC风险以及BRCA 1和BRCA 2在DNA修复中的重要性，更好的证据表明这些生活方式因素与BC风险之间的关联至关重要。我们使用考克斯比例风险模型，使用BRCA 1和BRCA 2突变携带者的大型国际合并队列，对酒精和烟草消费进行了回顾性（5，707例BRCA 1突变携带者; 3，525例BRCA 2突变携带者）和前瞻性（2，276例BRCA 1突变携带者; 1，610例BRCA 2突变携带者）分析。对于BRCA 1和BRCA 2突变携带者，除了与从不吸烟的经产妇女相比，在第一次足月妊娠（FFTP）前吸烟超过5年外，吸烟相关变量均与BC风险无关。对于BRCA 1突变携带者，回顾性分析（HRR）的HR为1.19（95%CI：1.02，1.39），前瞻性分析（HRP）的HR为1.36（95%CI：0.99，1.87）。对于BRCA 2突变携带者，在FFTP前吸烟超过5年显示出类似程度的相关性，但置信限更宽（HRR= 1.25，95%CI：1.01，1.55和HRP= 1.30，95%CI：0.83，2.01）。对于这两个携带者群体，饮酒与BC风险无关。在生育前几年吸烟会增加突变携带者的BC风险，这一发现值得进一步研究。
Tobacco smoking and alcohol consumption have been intensively studied in the general population to assess their effects on the risk of breast cancer (BC), but very few studies have examined these effects in BRCA1 and BRCA2 mutation carriers. Given the high BC risk for mutation carriers and the importance of BRCA1 and BRCA2 in DNA repair, better evidence on the associations of these lifestyle factors with BC risk is essential. Using a large international pooled cohort of BRCA1 and BRCA2 mutation carriers, we conducted retrospective (5,707 BRCA1 mutation carriers; 3,525 BRCA2 mutation carriers) and prospective (2,276 BRCA1 mutation carriers; 1,610 BRCA2 mutation carriers) analyses of alcohol and tobacco consumption using Cox proportional hazards models. For both BRCA1 and BRCA2 mutation carriers, none of the smoking-related variables was associated with BC risk, except smoking for more than five years before a first full-term pregnancy (FFTP) when compared to parous women who never smoked. For BRCA1 mutation carriers, the HR from retrospective analysis (HRR) was 1.19 (95%CI:1.02,1.39) and the HR from prospective analysis (HRP) was 1.36 (95%CI:0.99,1.87). For BRCA2 mutation carriers, smoking for more than five years before a FFTP showed an association of a similar magnitude, but the confidence limits were wider (HRR=1.25,95%CI:1.01,1.55 and HRP=1.30,95%CI:0.83,2.01). For both carrier groups, alcohol consumption was not associated with BC risk. The finding that smoking during the pre-reproductive years increases BC risk for mutation carriers warrants further investigation.