Hypoxic modulation of the cholinergic system in the cat carotid glomus cell.
Hypoxic modulation of the cholinergic system in the cat carotid glomus cell.
复制标题
猫颈动脉球细胞中胆碱能系统的缺氧调节。
DOI:
10.1007/0-387-31311-7_43
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发表时间:
2006
影响因子:
--
通讯作者:
Shirahata,Machiko
中科院分区:
文献类型:
--
作者:
Mendoza,JeffreyA;Chang,Irene;Shirahata,Machiko
AbstractThe carotid body is a primary sensory organ for arterial hypoxia. Chemosensory glomus cells in the carotid body release neurotransmitters, including ACh, in response to hypoxia. The release of neurotransmitters from the glomus cell, a putative chemoreceptor cell, appears to be triggered by an influx of calcium and subsequent increase in intracellular calcium ([Ca2+]i). Several reports indicate that L-type and some other types of voltage-gated calcium channels are responsible for neurotranmitter release from glomus cells (Gonzalez et al., 1994). These channels are activated by depolarization of the cell membrane. However, the speed and the degree of depolarization in glomus cells may not be sufficient to activate voltage-gated Ca2+channels at mild hypoxia (Chou et al., 1998), where afferent neural activity from the carotid body starts increasing. This discrepancy led us to search for other mechanisms which elevate [Ca2+]i followed by neurotransmitter release.
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DOI:
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发表时间:
1985
期刊:
影响因子:
--
作者:
G. Barany;F. Albericio
通讯作者:
F. Albericio
影响因子:
2.9
作者:
G. Matsueda;E. Haber
通讯作者:
E. Haber
DOI:
--
发表时间:
1983
期刊:
影响因子:
--
作者:
E. Brown;R. Sheppard;B. Williams
通讯作者:
B. Williams
DOI:
--
发表时间:
1985
期刊:
International journal of peptide and protein research
影响因子:
--
作者:
Tam,JP;Merrifield,RB
通讯作者:
Merrifield,RB
DOI:
--
发表时间:
1982
期刊:
影响因子:
--
作者:
E. Giralt;F. Albericio;E. Pedroso;C. Granier;J. Rietschoten
通讯作者:
J. Rietschoten