Studies on the human leukocyte antigens in patients with polycystic ovary syndrome in a Japanese population - Possible susceptibility of HLA-A11 and-DRB1*0403 to patient population with polycystic ovary syndrome
Studies on the human leukocyte antigens in patients with polycystic ovary syndrome in a Japanese population - Possible susceptibility of HLA-A11 and-DRB1*0403 to patient population with polycystic ovary syndrome
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DOI：
10.1111/j.1600-0897.2006.00369.x
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发表时间：
2006-04-01
影响因子：
3.6
通讯作者：
Tanaka, K
中科院分区：
文献类型：
--
作者：
Kaibe, M;Takakuwa, K;Tanaka, K
方法采用常规血清学方法对56例多囊卵巢综合征患者进行了人类白细胞抗原-A、-B、-C抗原检测。采用聚合酶链式反应-限制性片段长度多态性(PCR-RFLP)方法对68例PCOS患者进行了HLA-DRB1基因分型。作为对照人群，对237名健康人(男、女)进行了人类白细胞抗原-A、-B、-C抗原检测，并对292人进行了人类白细胞抗原-DRB1基因分型检测。结果PCOS患者的HLAA11和HLADRB1*0403的HLAA11和HLADRB1*0403的HLA值均显著高于对照组。PCOS患者的HLAB39携带率明显低于普通人群。
Problem The objective of this study was to identify the human leukocyte antigen (HLA) alleles that confer susceptibility or resistance to polycystic ovary syndrome (PCOS) in the Japanese population.Method of study HLA-A, -B and -C antigens were determined in 56 patients with PCOS using conventional serological method. HLA-DRB1 genotypes were determined using a polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method in 68 patients with PCOS. As a control population, 237 healthy individuals (males and females) were examined concerning HLA-A, -B and -C antigens, and 292 individuals were examined concerning HLA-DRB1 genotypes. The rate of possession of each antigen was compared between the two populations.Results The rate of possession of the HLA-A11 and HLA-DRB1*0403 in the patients with PCOS was significantly higher compared with that in the control group. The rate of possession of HLA-B39 in the patients with PCOS was significantly lower compared with that in the general population group.Conclusion Human leukocyte antigen systems appear to be linked to PCOS.