ISLET CELL ANTIBODIES AND DIABETES-MELLITUS IN PIMA-INDIANS
ISLET CELL ANTIBODIES AND DIABETES-MELLITUS IN PIMA-INDIANS
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DOI：
10.1007/bf01219743
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发表时间：
1979-01-01
期刊：
影响因子：
8.2
通讯作者：
DONIACH, D
中科院分区：
文献类型：
--
作者：
KNOWLER, WC;BENNETT, PH;DONIACH, D
胰岛细胞抗体和其他12种自身抗体在糖尿病诊断时，在46个皮马印第安人，年龄17-47岁，46个年龄性别匹配的非糖尿病对照。胰岛细胞抗体仅在2名20岁和25岁的糖尿病患者中发现，而46名对照者中没有发现。胰岛细胞抗体的受试者均无其他自身抗体。在14例（30%）糖尿病患者和14例对照组中发现至少1种自身抗体，但均与糖尿病无关。皮马印第安人的糖尿病，即使是25岁以下发病的，几乎完全是II型，因为这种疾病与胰岛细胞抗体、酮症酸中毒或胰岛素依赖无关。
Pancreatic islet cell antibodies and 12 other autoantibodies were measured at the time of diabetes diagnosis in 46 Pima Indians, aged 17-47 yr, and in 46 age-sex matched non-diabetic controls. Islet cell antibodies were found in only 2 diabetics, aged 20 and 25, compared with none of 46 controls. Neither of the subjects with islet cell antibodies had other autoantibodies. At least 1 type of autoantibody was found in 14 (30%) of the diabetics and in 14 controls, but none was significantly associated with diabetes. Diabetes in the Pima Indians, even those with an onset below 25 yr of age, is almost entirely of type II, in that the disease is not associated with islet cell antibodies, ketoacidosis or insulin dependence.