Early suppressive antiretroviral therapy in HIV infection is associated with measurable changes in the corpus callosum.
Early suppressive antiretroviral therapy in HIV infection is associated with measurable changes in the corpus callosum.
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DOI：
10.1007/s13365-014-0261-7
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发表时间：
2014-10
影响因子：
3.2
通讯作者：
Ragin AB
中科院分区：
文献类型：
--
作者：
Kelly SG;Taiwo BO;Wu Y;Bhatia R;Kettering CS;Gao Y;Li S;Hutten R;Ragin AB
本研究的目的是检查早期抑制性抗逆转录病毒治疗（ART）对脑结构和神经认知结果的影响。我们对HIV感染1年内的受试者进行了观察性研究。10名ART初治者和10名ART抑制者的年龄和感染持续时间相匹配，10名HIV血清阴性对照者的年龄相匹配。定量脑成像和神经认知数据进行了分析。受试者抑制ART减少胼胝体结构完整性的大分子和微观结构成像，更高的脑脊液百分比，更高的抑郁评分，和较低的功能表现。早期抑制性ART可能会改变HIV感染的神经系统进展轨迹，特别是在胼胝体。
The purpose of this study was to examine the impact of early suppressive antiretroviral therapy (ART) on brain structure and neurocognitive outcomes. We conducted an observational study of subjects within 1 year of HIV infection. Ten ART-naïve and 10 ART-suppressed individuals were matched for age and infection duration and age-matched to 10 HIV-seronegative controls. Quantitative brain imaging and neurocognitive data were analyzed. Subjects on suppressive ART had diminished corpus callosum structural integrity on macromolecular and microstructural imaging, higher cerebrospinal fluid percent, higher depression scores, and lower functional performance. Early suppressive ART may alter the trajectory of neurological progression of HIV infection, particularly in the corpus callosum.