The relation of physical activity to risk for symptomatic gallstone disease in men
The relation of physical activity to risk for symptomatic gallstone disease in men
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DOI：
10.7326/0003-4819-128-6-199803150-00001
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发表时间：
1998-03-15
影响因子：
39.2
通讯作者：
Willett, WC
中科院分区：
文献类型：
--
作者：
Leitzmann, MF;Giovannucci, EL;Willett, WC
背景：胆石病是美国的一个主要发病原因。女性胆结石的发病率是男性的两倍，但导致手术的严重胆道事件在两种性别中的发生率相同。目的：确定体力活动是否会降低男性有症状胆结石疾病的风险。设计：前瞻性队列研究。设置：美国男性健康专业人员。患者：从1986年到1994年，对45813名40至75岁的男性进行了跟踪调查。1986年、1988年、1990年、1992年和1994年邮寄的调查问卷询问了体力活动、胆石病发病率、年龄、体重、饮食和酒精摄入量，吸烟习惯，使用药物，并发生诊断的医疗条件以外的胆结石diseases.Results：828名男子报告有新症状的胆结石（诊断超声或放射摄影）或接受胆囊切除术的近期症状。在调整了多种混杂因素后，增加体力活动与症状性胆石病的风险呈负相关。当比较极端五分位数时，65岁以下的男性与风险的负相关性（多变量相对风险，0.58 [95%CI，0.44 - 0.78]）比65岁或以上的男性（相对风险，0.75 [CI，0.52 - 1.09]）更强。相比之下，久坐行为与症状性胆结石疾病的风险呈正相关。每周看电视超过40小时的男性比每周看电视少于6小时的男性患有症状的胆结石的风险更高（老年男性的相对风险为3.32 [CI，1.51至7.27];年轻男性的相对风险为1.58 [CI，0.38至6.48]）。体力活动可能在预防男性有症状的胆结石疾病方面发挥重要作用，甚至超出其控制体重的益处。这项研究的结果表明，34%的男性有症状的胆石病病例可以通过每周五次增加运动至30分钟的间歇性训练来预防。
Background: Gallstone disease is a major source of morbidity in the United States. Gallstones are twice as common in women as in men, but severe biliary events leading to surgery occur with equal frequency in the two sexes.Objective: To determine whether physical activity decreases risk for symptomatic gallstone disease in men.Design: Prospective cohort study.Setting: U.S. male health professionals.Patients: 45813 men 40 to 75 years of age were followed from 1986 to 1994.Measurements: Questionnaires mailed in 1986, 1988, 1990, 1992, and 1994 asked about physical activity, incidence of gallstone disease, age, body weight, dietary and alcohol intake, smoking habits, use of medications, and occurrence of diagnosed medical conditions other than gallstone disease.Results: 828 men reported having newly symptomatic gallstones (diagnosed by ultrasonography or radiography) or undergoing cholecystectomy for recent symptoms. After adjustment for multiple confounders, increased physical activity was inversely related to risk for symptomatic gallstone disease. When extreme quintiles were compared, men younger than 65 years of age had a stronger inverse association (multivariate relative risk, 0.58 [95% CI, 0.44 to 0.78]) with risk than did men 65 years of age or older (relative risk, 0.75 [CI, 0.52 to 1.09]). In contrast, sedentary behavior was positively related to risk for symptomatic gallstone disease. Men who watched television more than 40 hours per week had a higher risk for symptomatic gallstones than men who watched less than 6 hours per week (relative risk for older men, 3.32 [CI, 1.51 to 7.27]; relative risk for younger men, 1.58 [CI, 0.38 to 6.48]).Conclusions: Physical activity may play an important role in the prevention of symptomatic gallstone disease in men even beyond its benefit for control of body weight. The results of this study indicate that 34% of cases of symptomatic gallstone disease in men could be prevented by increasing exercise to 30 minutes of endurance-type training five times per week.