Entropy
Entropy
复制标题
DOI：
10.1016/j.bpa.2005.07.009
复制
发表时间：
2006-03-01
影响因子：
4.8
通讯作者：
Bein, Berthold
中科院分区：
文献类型：
--
作者：
Bein, Berthold
熵的概念起源于热力学，已成功地应用于脑电分析。各种熵算法已被用于临床研究，但到目前为止，商业上可用的监视器只存在频谱熵。通过计算EEG占主导地位的频谱部分（状态熵，SE）和总频谱（响应熵，RE）的两个不同值，M-熵模块声称提供有关患者皮质状态的有用信息以及镇痛充分性的间接测量。一般而言，已研究了熵用于定量各种GABA能静脉内诱导剂和挥发性麻醉剂（如丙泊酚和七氟烷）的麻醉药物作用，总体上发现与当前临床金标准双频指数（BIS）相当。在氯胺酮或一氧化二氮给药期间不得使用熵引导，因为与患者的意识状态没有可靠的相关性。到目前为止，RE作为疼痛刺激引起的EMG活动增加的替代品的有用性尚未得到证实。
The concept of entropy, originally derived from thermodynamics, has been successfully applied to EEG analysis. Various entropy algorithms have been used in clinical studies, but until now a commercially available monitor exists only for spectral entropy. By calculating two distinct values for the EEG dominated part of the spectrum (state entropy, SE) and the total spectrum (response entropy, RE), the M-Entropy module claims to provide useful information regarding the cortical state of the patient as well as an indirect measure of adequacy of analgesia. Generally, entropy has been studied for quantification of anaesthetic drug effect for various GABA-ergic i.v. induction agents and volatile anaesthetics like propofol and sevoflurane and overall was found comparable to the current clinical gold standard bispectral index (BIS). Entropy guidance may not be used during ketamine or nitrous oxide administration, since there is no reliable correlation to the patient's state of consciousness. The usefulness of RE as a surrogate for increased EMG activity due to painful stimulation has not been proven so far.