Enhancement of rat liver mitochondrial function by portal branch ligation secures subsequent extended hepatectomy.
Enhancement of rat liver mitochondrial function by portal branch ligation secures subsequent extended hepatectomy.
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通过门静脉分支结扎增强大鼠肝脏线粒体功能可确保随后的扩大肝切除术。
DOI：
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发表时间：
1991
期刊：
影响因子：
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通讯作者：
T. Ozawa
中科院分区：
文献类型：
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作者：
T. Katoh;M. Tanaka;Y. Nimura;M. Kanai;M. Nagino;T. Ozawa
我们研究了门静脉分支结扎对大鼠肝线粒体功能和随后的扩大肝切除术的影响。在闭塞的叶中，结扎后线粒体功能立即受到抑制。在未闭塞的叶中，线粒体功能增强并在结扎后两天达到最大值。这种增强与能量转换复合物的酶活性和亚基数量的增加以及线粒体 DNA 含量的增加有关。连接提高了肝切除术后的存活率和通过乙酰乙酸与β-羟基丁酸的比率监测的线粒体氧化还原状态。这些结果表明，门静脉分支结扎增强线粒体功能满足了肝脏再生的能量需求。
We have examined the effects of portal branch ligation on liver mitochondrial function and on subsequent extended hepatectomy in rat. In the occluded lobes, mitochondrial function was depressed immediately after the ligation. In the unoccluded lobes, mitochondrial function was enhanced and reached the maximum two days after the ligation. This enhancement was associated with increases in the enzymic activities and subunit amounts of the energy-transducing complexes, and with increase in mitochondrial DNA content. The ligation improved both survival rate and mitochondrial redox state monitored by the ratio of acetoacetate to beta-hydroxybutyrate after hepatectomy. These results suggest that the enhancement of mitochondrial function by portal branch ligation fills the energy demand for liver regeneration.