Effect of Perioperative CEA and CA24-2 on Prognosis of Early Resectable Pancreatic Ductal Adenocarcinoma
Effect of Perioperative CEA and CA24-2 on Prognosis of Early Resectable Pancreatic Ductal Adenocarcinoma
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围手术期CEA和CA24-2对早期可切除胰管腺癌预后的影响
DOI：
10.7150/jca.33767
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发表时间：
2020
影响因子：
3.9
通讯作者：
Gao Chuntao
中科院分区：
文献类型：
--
作者：
Li Xiaojie;Li Shengnan;Liu Lili;Hong Jiahui;Zhao Tiansuo;Gao Chuntao
可切除的胰腺导管腺癌（PDAC）患者在根治性切除后显示出不同的预后。目前，癌症分级和手术标准在很大程度上取决于成像和解剖诊断。因此，建立一个具有可靠的围手术期预后因素的模型来评估PDAC患者的预后是必要的。在这项研究中，招募了103名接受根治性切除术的PDAC患者。评价术前癌胚抗原（CEA）、术后CA 24 -2及两者联合检测对总生存期（OS）的预测价值。多因素分析发现，CEA前和CA 24 -2后均为OS的独立预后因素。Kaplan-Meier分析显示，CEA、CA 24 -2及两者联合升高与OS不良相关，CEA、CA 24 -2联合升高患者的预后较CEA前或CA 24 -2后升高患者差。因此，我们得出结论，CEA和CA 24 -2的组合可以用作I期和II期可切除PDAC患者的预后因素。
Patients with resectable pancreatic ductal adenocarcinoma (PDAC) show differential prognosis after radical resection. Currently, cancer grading and surgical criteria depend heavily on imaging and anatomical diagnosis. It's essential to set up a model with reliable prognostic factors during the perioperative period to assess prognosis in PDAC patients. In this study, 103 patients diagnosed with PDAC who underwent radical resection were recruited. The predictive value of preoperative carcinoembryonic antigen (CEA), postoperative CA24-2 and the combination of two for overall survival (OS) were evaluated. Both pre-CEA and post-CA24-2 were found to be independent prognostic factors for OS according to multivariate analyses. Kaplan-Meier analysis revealed that CEA and CA24-2 as well as the combination of two were correlated with poor OS. In addition, patients with both markers elevated have worse prognosis than patients with either pre-CEA or post-CA24-2 elevated. Thus, we concluded that the combination of CEA and CA24-2 can be used as a prognostic factor for stage I and II resectable PDAC patients.