Molecular, Cellular and Functional Effects of Radiation-Induced Brain Injury: A Review.
Molecular, Cellular and Functional Effects of Radiation-Induced Brain Injury: A Review.
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辐射引起的脑损伤的分子，细胞和功能效应：综述。
DOI：
10.3390/ijms161126068
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发表时间：
2015-11-24
影响因子：
5.6
通讯作者：
Adamkov M
中科院分区：
文献类型：
--
作者：
Balentova S;Adamkov M
放射治疗是原发性脑肿瘤和转移瘤最有效的非手术治疗。临床前研究为了解辐射引起的中枢神经系统损伤的发病机制提供了有价值的见解。放射性脑损伤可损伤脑的神经元、神经胶质和血管区室，并可导致分子、细胞和功能的改变。鉴于其在记忆和成人神经发生中的核心作用，大多数研究都集中在海马体上。这些结果表明，脑放射治疗中海马回避可以预防放射性认知障碍。然而，多项啮齿动物研究表明，这个问题更为复杂。由于辐射诱导的认知障碍反映了海马和非海马区室，因此研究不同脑区的分子、细胞和功能修饰以及它们在临床相关剂量和时间表下的整合至关重要。我们在这里提供了一个文献综述，包括我们以前发表的结果，以支持临床前研究结果转化为临床实践，并改善脑肿瘤患者的身心状况。
Radiation therapy is the most effective non-surgical treatment of primary brain tumors and metastases. Preclinical studies have provided valuable insights into pathogenesis of radiation-induced injury to the central nervous system. Radiation-induced brain injury can damage neuronal, glial and vascular compartments of the brain and may lead to molecular, cellular and functional changes. Given its central role in memory and adult neurogenesis, the majority of studies have focused on the hippocampus. These findings suggested that hippocampal avoidance in cranial radiotherapy prevents radiation-induced cognitive impairment of patients. However, multiple rodent studies have shown that this problem is more complex. As the radiation-induced cognitive impairment reflects hippocampal and non-hippocampal compartments, it is of critical importance to investigate molecular, cellular and functional modifications in various brain regions as well as their integration at clinically relevant doses and schedules. We here provide a literature overview, including our previously published results, in order to support the translation of preclinical findings to clinical practice, and improve the physical and mental status of patients with brain tumors.