Neuropeptide B mediates female sexual receptivity in medaka fish, acting in a female-specific but reversible manner
Neuropeptide B mediates female sexual receptivity in medaka fish, acting in a female-specific but reversible manner
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DOI：
10.7554/elife.39495
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发表时间：
2019-08-06
期刊：
影响因子：
7.7
通讯作者：
Okubo, Kataaki
中科院分区：
文献类型：
--
作者：
Hiraki-Kajiyama, Towako;Yamashita, Junpei;Okubo, Kataaki
雄性和雌性动物表现出天生的性别特异性交配行为。在硬骨鱼中，改变成年性类固醇环境可以有效地逆转性别典型的交配行为，这表明它们的大脑在成年时具有显着的性不稳定性。在硬骨鱼青鳉中，神经肽B（NPB）在与交配行为有关的脑核团中表达。在这里，我们表明，NPB是雌激素作用于女性交配行为的直接介质，作用于女性特定的，但可逆的方式。调节机制的分析表明，女性特异性表达的NPB是依赖于雌激素通过雌激素反应元件的直接转录激活，并在响应于成人性类固醇环境的变化被逆转。NPB基因敲除的行为学研究表明，雌性特异性NBP介导雌性对雄性求爱的接受性。雌性特有的NPB信号可能是硬骨鱼类两性异形和交配行为不稳定性的神经回路的关键因素。
Male and female animals display innate sex-specific mating behaviors. In teleost fish, altering the adult sex steroid milieu can effectively reverse sex-typical mating behaviors, suggesting remarkable sexual lability of their brains as adults. In the teleost medaka, neuropeptide B (NPB) is expressed female-specifically in the brain nuclei implicated in mating behavior. Here, we demonstrate that NPB is a direct mediator of estrogen action on female mating behavior, acting in a female-specific but reversible manner. Analysis of regulatory mechanisms revealed that the female-specific expression of NPB is dependent on direct transcriptional activation by estrogen via an estrogen-responsive element and is reversed in response to changes in the adult sex steroid milieu. Behavioral studies of NPB knockouts revealed that female-specific NBP mediates female receptivity to male courtship. The female-specific NPB signaling identified herein is presumably a critical element of the neural circuitry underlying sexual dimorphism and lability of mating behaviors in teleosts.