Bicuculline application affects discharge patterns, rate-intensity functions, and frequency tuning characteristics of bat auditory cortical neurons
Bicuculline application affects discharge patterns, rate-intensity functions, and frequency tuning characteristics of bat auditory cortical neurons
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DOI：
10.1016/s0378-5955(00)00197-0
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发表时间：
2000-12-01
期刊：
影响因子：
2.8
通讯作者：
Jen, PHS
中科院分区：
文献类型：
--
作者：
Chen, QC;Jen, PHS
本研究探讨了双球茎碱对大褐蝙蝠听觉皮层听觉反应特性的影响。所有的听觉皮层神经元在4 ms的声音刺激下释放1-2或3-7个脉冲。高最佳频率的皮质神经元往往具有高的最低阈值。双曲线碱的应用增加了所有皮层神经元的脉冲数量，缩短了反应潜伏期，并改变了一半皮层神经元的放电模式。双曲线的应用提高了速率强度函数，但不同程度地降低了延迟强度函数。阈值-频率调谐曲线（FTCs）呈v形、上阈值或双峰。阈值型ftc和脉冲型ftc是互为镜像的。双库线的应用扩大并提高了脉冲- ftcs，但降低了阈值- ftcs，导致Q(n)值显著降低。在正交插入电极中测定皮层神经元的阈值-FTCs非常相似，在双球茎碱应用期间扩展的FTCs也非常相似。讨论了gaba能抑制形成皮层神经元这些反应特性的可能机制。(C) 2000 Elsevier Science B.V.版权所有
This study examined the effect of bicuculline application on the auditory response properties in the auditory cortex of the big brown bat, Eptesicus fuscus. All auditory cortical neurons studied discharged either 1-2 or 3-7 impulses to 4 ms sound stimuli. Cortical neurons with high best frequencies tended to have high minimum thresholds. Bicuculline application increased the number of impulses and shortened the response latencies of all cortical neurons as well as changing the discharge patterns of half of the cortical neurons studied. Bicuculline application raised the rate-intensity functions but lowered the latency-intensity functions to varying degrees. Threshold-frequency tuning curves (FTCs) were either V-shaped, upper threshold or double-peaked. Threshold-FTCs and impulse-FTCs were mirror-images of each other. Bicuculline application expanded and raised the impulse-FTCs but lowered the threshold-FTCs, resulting in significantly decreased Q(n) values. Threshold-FTCs of cortical neurons determined within an orthogonally inserted electrode were very similar and expanded FTCs during bicuculline application were also very similar. Possible mechanisms for the contribution of GABAergic inhibition to shaping these response properties of cortical neurons are discussed. (C) 2000 Elsevier Science B.V. All rights reserved.