Comparison of the triglyceride lipase of liver, adipose tissue, and postheparin plasma.
Comparison of the triglyceride lipase of liver, adipose tissue, and postheparin plasma.
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肝脏、脂肪组织和肝素后血浆的甘油三酯脂肪酶的比较。
DOI：
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发表时间：
1972
影响因子：
6.5
通讯作者：
D. Fredrickson
中科院分区：
文献类型：
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作者：
J. Larosa;R. Levy;H. G. Windmueller;D. Fredrickson
肝素释放甘油三酯脂肪酶从三个来源，脂肪组织，肝脏和肝素后血浆，进行比较。肝素释放的甘油三酯脂肪酶与脂肪组织中的肝素释放的甘油三酯脂肪酶在几个主要方面不同。这些差异包括对抑制剂的反应和对培养液中高密度脂蛋白的反应。肝素释放的甘油三酯脂肪酶，与脂肪组织的相比，对脂蛋白底物相对无活性。肝素后血浆中的甘油三酯脂肪酶表现出与肝脏相似的特性。这些研究提出了一种可能性，即肝素后血浆中的甘油三酯脂肪酶可能是异质的，肝素后血浆中的酶水平可能不能准确地反映血浆中甘油三酯的清除能力。
Heparin-released triglyceride lipase from three sources, adipose tissue, liver, and postheparin plasma, was compared. Heparin-released triglyceride lipase from liver differed in several major respects from that in adipose tissue. These differences included response to inhibitors and to high density lipoprotein in the incubation media. Heparin-released triglyceride lipase from liver, when compared with that from adipose tissue, was relatively inactive against lipoprotein substrates. The triglyceride lipase from postheparin plasma exhibited properties more like those of liver. These studies raise the possibility that triglyceride lipase in postheparin plasma may be heterogeneous and that levels of the enzyme in postheparin plasma may not accurately reflect the capacity for clearance of triglyceride from the plasma.