In Vitro Activity of Gepotidacin, a Novel Triazaacenaphthylene Bacterial Topoisomerase Inhibitor, against a Broad Spectrum of Bacterial Pathogens
In Vitro Activity of Gepotidacin, a Novel Triazaacenaphthylene Bacterial Topoisomerase Inhibitor, against a Broad Spectrum of Bacterial Pathogens
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DOI：
10.1128/aac.02820-15
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发表时间：
2016-03-01
影响因子：
4.9
通讯作者：
Sahm, D. F.
中科院分区：
文献类型：
--
作者：
Biedenbach, D. J.;Bouchillon, S. K.;Sahm, D. F.
Gepotidacin通过不同于氟喹诺酮类的方式抑制细菌DNA复制。通过肉汤和琼脂稀释法检测吉泊替辛和对照药物对临床分离株的抑制作用。吉泊替辛的体外活性与甲氧西林敏感和耐甲氧西林金黄色葡萄球菌（分别为MSSA和MRSA）分离株（MIC 90，0.5 μ g/ml）相当。吉泊替辛对指定细菌的MIC（90）如下（微克/毫升）：化脓性链球菌，0.25;大肠杆菌，2;卡他莫拉菌，
Gepotidacin inhibits bacterial DNA replication through a mode different from that of fluoroquinolones. Gepotidacin and comparators were tested by broth and agar dilution against clinical isolates. The in vitro activities of gepotidacin were comparable against methicillin-susceptible and -resistant Staphylococcus aureus (MSSA and MRSA, respectively) isolates (MIC90, 0.5 mu g/ml). The gepotidacin MIC(90)s were as follows (in micrograms per milliliter) for the indicated bacteria: Streptococcus pyogenes, 0.25; Escherichia coli, 2; Moraxella catarrhalis,