Bilateral parotid gland enlargement and hyperlipoproteinemia.
Bilateral parotid gland enlargement and hyperlipoproteinemia.
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双侧腮腺肿大，高脂蛋白血症。
DOI：
10.1001/jama.1969.03160370051010
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发表时间：
1969
期刊：
影响因子：
--
通讯作者：
N. Talal
中科院分区：
文献类型：
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作者：
H. B. Kaltreider;N. Talal
干燥综合征是医生的初步诊断，他们转诊了5名双侧非炎性腮腺肿大的患者。这一诊断在任何情况下都没有得到证实。所有5例患者均出现血浆甘油三酯浓度升高和轻度舒张期高血压。经常出现酒精饮料摄入量增加、葡萄糖耐量异常和中度肥胖。在两个活检标本中观察到腮腺组织被脂肪大量替代。限制热量、酒精饮料和碳水化合物的热量百分比导致3名患者的腮腺大小消退，观察时间超过3个月。另一名患者在五周内腮腺大小出现了适度的短期减少。这种饮食方案也改善了高胆固醇血症。
Sjogren's syndrome was the initial diagnosis of the physicians who referred five patients with bilateral, noninflammatory parotid gland enlargement. This diagnosis was not confirmed in any case. All five patients had elevated plasma triglyceride concentrations and mild diastolic hypertension. Increased intake of alcoholic beverages, abnormal glucose tolerance, and moderate obesity were frequently present. Massive replacement of the parotid gland tissue by fat was observed in two biopsy specimens. Restriction of calories, alcoholic beverages, and the percent of calories from carbohydrate resulted in regression of parotid gland size in three patients observed for more than three months. A modest short-term reduction in size of the parotid gland occurred in one other patient over a five-week period. Hypertriglyceridemia was also ameliorated by this dietary regimen.