Trazodone. A comparative clinical and predictive study.
Trazodone. A comparative clinical and predictive study.
复制标题
曲唑酮。
DOI：
--
复制
发表时间：
1984
影响因子：
6.7
通讯作者：
S. Ankier
中科院分区：
文献类型：
--
作者：
T. A. Kerr;H. Mcclelland;D. Stephens;S. Ankier
比较曲唑酮与阿米替林对74例抑郁症患者的临床疗效及耐受性。曲唑酮和阿米替林的日剂量分别为150-300毫克和75-225毫克，65岁以上患者服用半剂量胶囊。接受曲唑酮和阿米替林治疗的患者分别有25例和29例完成了6周的治疗期。采用汉密尔顿抑郁评定量表（HDRS）、Zung抑郁量表、视觉模拟量表和全球评估量表测量抗抑郁活性。曲唑酮和阿米替林均有效，但在抗抑郁作用方面没有统计学差异。此外，神经性或内源性抑郁症患者对两种治疗的反应都一样好。曲唑酮在阿米替林出现的持续性口干和严重的精神不良反应方面较不麻烦。建议患者饭后服用曲唑酮。
The clinical efficacy and tolerability of trazodone and amitriptyline were compared in 74 hospital patients suffering from depressive illness. The daily doses of trazodone and amitriptyline were 150-300 mg and 75-225 mg, respectively, with half-strength capsules for patients over the age of 65 years. Twenty-five and 29 patients receiving trazodone and amitriptyline, respectively, completed the 6 week treatment period. Antidepressant activity was measured using the Hamilton Depression Rating Scale (HDRS), the Zung Scale of Depression, visual analogue scales and a Global Assessment Scale. Trazodone and amitriptyline were both effective but not statistically different from each other in terms of antidepressant action. Moreover, patients with neurotic or endogenous depression responded equally well on either treatment. Trazodone was less troublesome in respect of the persistent dry mouth and severe adverse psychiatric reactions which occurred with amitriptyline. Patients should be advised to take trazodone after meals.