Psychologic and neuropsychologic impact of autologous bone marrow transplantation
Psychologic and neuropsychologic impact of autologous bone marrow transplantation
复制标题
DOI：
10.1200/jco.1996.14.5.1457
复制
发表时间：
1996-05-01
影响因子：
45.3
通讯作者：
Mills, L
中科院分区：
文献类型：
--
作者：
Ahles, TA;Tope, DM;Mills, L
目的：本研究的主要目的是评估接受自体骨髓移植（ABMT）治疗的患者的心理和神经心理功能。54例血液病或乳腺癌患者在ABMT前、治疗中期完成了一系列心理和神经心理测试（骨髓再输注后1 - 3天）和出院前（出院前1 ~ 2天内）。结果：移植前数据的分析显示，状态-特质焦虑量表（STAI）和情绪状态量表（POMS）的得分显著较高然而，当患者根据先前暴露于颅辐射和/或鞘内化疗分组时，没有发现神经心理学测量的基线差异。对34名患者进行了移植前、骨髓返回后和出院前的系列评估。对于心理学数据，在基线时，患有血液疾病的患者往往比乳腺癌患者更痛苦，但随着时间的推移变得不那么痛苦。相比之下，乳腺癌患者在基线时相对不那么痛苦，在治疗中表现出痛苦的显著增加，并在出院前评估时恢复到基线水平，评估高阶认知功能的神经心理学指标评分通常随时间推移而恶化。结果表明，当将血液系统疾病患者与乳腺癌患者进行比较时，对心理测量的反应存在差异，然而，在治疗过程中，两组在神经心理学测量方面表现出普遍下降。(C)1996年，美国临床肿瘤学会。
Purpose: The major purpose of the current study was to evaluate the psychologic and neuropsychologic functioning of patients undergoing treatment with autologous bone marrow transplantation (ABMT).Patients and Methods: Fifty-four patients with hematologic disorders or breast cancer completed a battery of psychologic and neuropsychologic tests before ABMT, at midtreatment (1 to 3 days following bone marrow reinfusion), and predischarge (within 1 to 2 days before discharge from the hospital).Results: Analysis of pretransplant data showed significantly higher scores on the State-Trait Anxiety Inventory (STAI) and Profile of Mood States (POMS) for patients with hematologic disorders as compared with patients with breast cancer, However, no baseline differences on neuropsychologic measures were found when patients were divided into groups based on prior exposure to cranial radiation and/or intrathecal chemotherapy, Serial evaluations at pretransplant, following return of bone marrow, and at predischarge were available for 34 patients, For the psychologic data, patients with hematologic disorders tended to be more distressed than breast cancer patients at baseline, but became less distressed over time, By contrast, breast cancer patients were relatively less distressed at baseline, demonstrated a significant increase in distress midtreatment, and returned to baseline levels at predischarge assessment, Scores on neuropsychologic measures that assessed higher order cognitive functioning generally worsened over time.Conclusion: The results suggest a differential response on psychologic measures when comparing patients with hematologic disorders with those with breast cancer, However, both groups demonstrated a general decline in performance on neuropsychologic measures over the course of treatment. (C) 1996 by American Society of Clinical Oncology.