Associated Malignancies in Patients with Waldenstrom's Macroglobulinemia and Their Kin
Associated Malignancies in Patients with Waldenstrom's Macroglobulinemia and Their Kin
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DOI：
10.3816/clml.2011.n.016
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发表时间：
2011-02-01
影响因子：
2.7
通讯作者：
Treon, Steven P.
中科院分区：
文献类型：
--
作者：
Hanzis, Christina;Ojha, Rohit P.;Treon, Steven P.
我们研究了924例Waldenstrom巨球蛋白血症（WM）患者及其亲属中其他恶性肿瘤的发病率。共有225例（24.3%）患者有≥ 1个额外的恶性肿瘤，其中63%在WM诊断之前。最常见的性别校正恶性肿瘤为前列腺（9.4%）、乳腺（8.0%）、非黑色素瘤皮肤（7.1%）、血液学（2.8%）、黑色素瘤（2.2%）、肺（1.4%）和甲状腺（1.1%）。在恶性血液病中，13例弥漫性大B细胞淋巴瘤和4例急性髓性白血病均在WM后确诊，且与治疗相关。家族性WM亚组分析显示，散发性WM患者前列腺癌的发病率较高（P = 0.046），而家族性WM患者肺癌的发病率较高（P = 0.0043）。在家族性WM患者的亲属中，髓系白血病的发病率增加（P <0.0001）。这些数据揭示了特定的癌症与WM的关联，并为旨在描绘共同遗传基础的探索性研究提供了基础。此外，这些研究表明，特定的癌症集群的基础上家族易感性WM。
We examined the incidence of other malignancies in 924 Waldenstrom's Macroglobulinemia (WM) patients and their kin. A total of 225 (24.3%) patients had >= 1 additional malignancy, with 63% predating the WM diagnosis. The most common gender-adjusted malignancies were prostate (9.4%), breast (8.0%), non-melanoma skin (7.1%), hematologic (2.8%), melanoma (2.2%), lung (1.4%) and thyroid 1.1%). Among hematologic malignancies, all 13 cases of diffuse large B-cell lymphoma and 4 cases of acute myelogenous leukemia were diagnosed after WM, and were therapy-related. Familial WM subgroup analysis showed a higher incidence of prostate cancer (P = .046) in sporadic WM patients, while patients with familial WM had a higher incidence of lung cancer (P = .0043). An increased incidence of myeloid leukemias (P < .0001) was reported among kin of familial WM patients. These data reveal specific cancer associations with WM, and provide a basis for exploratory studies aimed at delineating a common genetic basis. Additionally, these studies suggest specific cancer clustering based on familial predisposition to WM.