High-Strength and High-Toughness Double-Cross-Linked Cellulose Hydrogels: A New Strategy Using Sequential Chemical and Physical Cross-Linking
High-Strength and High-Toughness Double-Cross-Linked Cellulose Hydrogels: A New Strategy Using Sequential Chemical and Physical Cross-Linking
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高强度和高韧性双交联纤维素水凝胶：采用顺序化学和物理交联的新策略
DOI：
10.1002/adfm.201601645
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发表时间：
2016-09-13
影响因子：
19
通讯作者：
Cai, Jie
中科院分区：
文献类型：
--
作者：
Zhao, Dan;Huang, Junchao;Cai, Jie
多糖基水凝胶由于其固有的生物相容性、可生物降解性和无毒性而具有多种优点。如果多糖基水凝胶能够同时满足实际应用中对力学性能和细胞相容性的要求，则可以提高多糖基水凝胶的可行性。本文描述了双交联（DC）纤维素水凝胶的结构，使用顺序的化学和物理交联，导致DC纤维素水凝胶在机械上优于单交联纤维素水凝胶。证明了DC纤维素水凝胶中化学交联结构域和物理交联结构域的形成和空间分布。环氧氯丙烷与纤维素无水葡萄糖单位的摩尔比和乙醇水溶液的浓度是获得机械强度高、韧性好的直流纤维素水凝胶的两个关键参数。用压缩和拉伸模型描述了直流纤维素水凝胶在加载-卸载循环下的力学性能。讨论了双交联增韧的可能机理。
Polysaccharide-based hydrogels have multiple advantages because of their inherent biocompatibility, biodegradability, and non-toxicic properties. The feasibility of using polysaccharide-based hydrogels could be improved if they could simultaneously fulfill the mechanical property and cell compatibility requirements for practical applications. Herein, the construction of double-cross-linked (DC) cellulose hydrogels is described using sequential chemical and physical cross-linking, resulting in DC cellulose hydrogels that are mechanically superior to single-cross-linked cellulose hydrogels. The formation and spatial distribution of chemically cross-linked domains and physically cross-linked domains within the DC cellulose hydrogels are demonstrated. The molar ratio of epichlorohydrin to anhydroglucose units of cellulose and the concentration of the aqueous ethanol solution are two critical parameters for obtaining mechanically strong and tough DC cellulose hydrogels. The mechanical properties of the DC cellulose hydrogels under loading-unloading cycles are described using compression and tension models. The possible toughening mechanism of double-cross-linking is discussed.