THE SPATIAL-ORGANIZATION OF THE PERIPHERAL OLFACTORY SYSTEM OF THE HAMSTER .2. RECEPTOR SURFACES AND ODORANT PASSAGEWAYS WITHIN THE NASAL CAVITY
THE SPATIAL-ORGANIZATION OF THE PERIPHERAL OLFACTORY SYSTEM OF THE HAMSTER .2. RECEPTOR SURFACES AND ODORANT PASSAGEWAYS WITHIN THE NASAL CAVITY
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DOI：
10.1016/0361-9230(94)90060-4
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发表时间：
1994-01-01
影响因子：
3.8
通讯作者：
MACRIDES, F
中科院分区：
文献类型：
--
作者：
CLANCY, AN;SCHOENFELD, TA;MACRIDES, F
通过描述性和形态学分析的一个完整的立体定位定义的冠状面，矢状面和水平截面通过口鼻部的一系列仓鼠鼻腔内的嗅觉受体表面和气味通道的空间组织进行了研究。这些分析表明，每个腔的尾侧三分之二被分成两个纵向定向的内侧和外侧通道。排列在这两个通道上的嗅粘膜分别选择性地投射到主嗅球（MOB）的内侧和外侧。此外，尾侧隐窝的筛鼻甲骨形成高度回旋的通道，衬有腹侧突出的粘膜，位于腹侧、外侧和背侧，相对光滑的中央通道衬有背侧突出的粘膜。嗅觉定位图使内侧和外侧嗅觉空间的表示等同于MOB，但在MOB上给予背侧突出粘膜内衬的平滑空间比更膨胀的腹侧突出粘膜内衬的回旋空间不成比例地更大。最近描述的空间分布的气味受体蛋白的探针符合密切这种组织，给人以信任的想法，即，optimotopy是代表的MOB的气味分子的具体分子特征的基础。
The spatial organization of olfactory receptor surfaces and odorant passageways within the nasal cavity was studied in hamsters through descriptive and morphometric analyses of a complete stereotaxically defined series of coronal, sagittal, and horizontal sections through the snout. These analyses reveal that the caudal two-thirds of each cavity is divided into two longitudinally oriented medial and lateral channels. The olfactory mucosa that lines these two channels projects selectively onto the medial and lateral halves of the main olfactory bulb (MOB), respectively. Moreover, the ethmoturbinates of the caudal recesses create highly convoluted channels, lined by ventrally projecting mucosa, that lie ventral, lateral, and dorsal to a relatively smooth central channel lined by dorsally projecting mucosa. The rhinotopic map makes equivalent representations of medial and lateral olfactory space to the MOB but gives the smooth space lined by dorsally projecting mucosa a disproportionately larger representation on the MOB than the convoluted space lined by the more expansive ventrally projecting mucosa. Recent descriptions of the spatial distribution of probes for odorant receptor proteins conform closely to this organization, giving credence to the idea that rhinotopy is a basis for representing to the MOB the specific molecular features of odorant molecules.